Results 61 to 70 of about 8,524,151 (285)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 2013 Given integers b, c, g, and n, we construct a manifold M containing a c-component link L so that there is a bridge surface Sigma for (M,L) of genus g that intersects L in 2b points and has distance at least n.
Blair, Ryan +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
West African Journal of Open and Flexible Learning, 2022 Authentic Assessment (AA) has been heralded as the form of assessment that reflects the real world in classroom learning. Recognising this, the Commonwealth of Learning (COL), in collaboration with the National Universities Commission (NUC) in Nigeria ...
Mobolanle Ebunoluwa Sotunsa +4 more
doaj
, 2003 In this paper, we prove that two different observers don't equally measure the distance between two points A and B. For this, we introduce some postulates and obtain a new formula to show distance between A and B. In this formula, radius of universe, n, is entered such that if n tends to infinity the ordinary distance is obtained.
Akbari, M., Darvishi, M. T.
openaire +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Improved Heterogeneous Distance Functions [PDF]
, 1996 Instance-based learning techniques typically handle continuous and linear input values well, but often do not handle nominal input attributes appropriately. The Value Difference Metric (VDM) was designed to find reasonable distance values between nominal
Martinez, T. R., Wilson, D. R.
core +3 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source