Results 51 to 60 of about 2,356,418 (271)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Delighting Our Customers: Building Services Collaboratively with Learners at a Distance [PDF]
, 2016 The Open University (OU) is the largest academic institution dedicated to distance learning in the United Kingdom, with over 173,000 students. Distance learning students can provide a unique perspective on the experience of the library.
Dick, Sam, Killick, Selena
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Journal of Open, Flexible and Distance Learning, 2012 Column about conferences events and new publications in distance learning.
Glenise Dreaver, Terry Hearn
doaj +2 more sources
Harnessing the creativity of digital multimedia tools in distance learning [PDF]
, 2012 Over the past few decades, advances in information and communication technologies, and particularly the digitisation of information, have brought about radical changes in the way media can be produced, distributed and shared. The exchange of information,
Kouadri Mostéfaoui, Soraya +1 more
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Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Vertical Head Movements Influence Memory Performance for Words With Emotional Content
Frontiers in Psychology, 2019 Numerous studies have found an association between valence and the vertical dimension of space (good-up, bad-down). This association has also been linked to sensorimotor experiences (e.g., body movements).
Laura K. Globig +2 more
doaj +1 more source
Independent Distance Learning – is it worth it? [PDF]
, 2013 This paper describes an approach to the management of the development of independent distance learning programmes (IDL) adopted by the University of Sunderland.
Neal, Ian, Williamson, Phil
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah +7 more
wiley +1 more source