Results 91 to 100 of about 353,852 (269)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

EduDCM: A Novel Framework for Automatic Educational Dialogue Classification Dataset Construction via Distant Supervision and Large Language Models

Applied Sciences
Educational dialogue classification is a critical task for analyzing classroom interactions and fostering effective teaching strategies. However, the scarcity of annotated data and the high cost of manual labeling pose significant challenges, especially ...
Changyong Qi, Longwei Zheng, Yuang Wei, Haoxin Xu, Peiji Chen, Xiaoqing Gu   +5 more
doaj   +1 more source

Few Clean Instances Help Denoising Distant Supervision

, 2022
Existing distantly supervised relation extractors usually rely on noisy data for both model training and evaluation, which may lead to garbage-in-garbage-out systems. To alleviate the problem, we study whether a small clean dataset could help improve the quality of distantly supervised models.
Liu, Yufang, Huang, Ziyin, Wang, Yijun, Sun, Changzhi, Lan, Man, Wu, Yuanbin, Mou, Xiaofeng, Wang, Ding   +7 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Reinforcement Learning for Distantly Supervised Relation Extraction

IEEE Access, 2019
Relation extraction is a task of identifying semantic relations between entity pairs from plain text, which can benefit a lot of AI applications such as knowledge base construction and answer questioning. The distant supervision strategy is introduced to
Tingting Sun, Chunhong Zhang, Yang Ji, Zheng Hu   +3 more
doaj   +1 more source

Effective Distant Supervision for Temporal Relation Extraction

, 2020
A principal barrier to training temporal relation extraction models in new domains is the lack of varied, high quality examples and the challenge of collecting more. We present a method of automatically collecting distantly-supervised examples of temporal relations.
Zhao, Xinyu, Lin, Shih-ting, Durrett, Greg   +2 more
openaire   +2 more sources

Large Discourse Treebanks from Scalable Distant Supervision

, 2022
Discourse parsing is an essential upstream task in Natural Language Processing with strong implications for many real-world applications. Despite its widely recognized role, most recent discourse parsers (and consequently downstream tasks) still rely on small-scale human-annotated discourse treebanks, trying to infer general-purpose discourse ...
Huber, Patrick, Carenini, Giuseppe
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source