Results 71 to 80 of about 14,157 (261)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Equations for a potential algebraic approach to the twin prime conjecture. Addendum to: "On the numbers that determine the distribution of twin primes" [PDF]

Surveys in Mathematics and its Applications
This is an Addendum to: Article: On the numbers that determine the distribution of twin primes Author: Antonie Dinculescu Published in: Surveys in Mathematics and its Applications, 13 (2018), 171–181. Full text:
Antonie Dinculescu
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Large sieve inequalities for exceptional Maass forms and the greatest prime factor of $n^2+1$

Forum of Mathematics, Pi
We prove new large sieve inequalities for the Fourier coefficients $\rho _{j\mathfrak {a}}(n)$ of exceptional Maass forms of a given level, weighted by sequences $(a_n)$ with sparse Fourier transforms – including two key types of sequences ...
Alexandru Pascadi
doaj   +1 more source

On a Dynamical Approach to Some Prime Number Sequences

Entropy, 2018
We show how the cross-disciplinary transfer of techniques from dynamical systems theory to number theory can be a fruitful avenue for research. We illustrate this idea by exploring from a nonlinear and symbolic dynamics viewpoint certain patterns ...
Lucas Lacasa, Bartolome Luque, Ignacio Gómez, Octavio Miramontes   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Variants on Andrica’s Conjecture with and without the Riemann Hypothesis

Mathematics, 2018
The gap between what we can explicitly prove regarding the distribution of primes and what we suspect regarding the distribution of primes is enormous. It is (reasonably) well-known that the Riemann hypothesis is not sufficient to prove Andrica’s ...
Matt Visser
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Conjetura de GOLDBACH, números naturales y teorema de números primos

Revista Bases de la Ciencia, 2019
Mediante el uso de Geogebra en el siguiente manuscrito se realiza un análisis de la conjetura de Goldbach, posteriormente se comprueba mediante expresiones algebraicas que siempre existe una cantidad mínima de elementos primos que hacen que se cumpla la ...
Yandry Marcelo Intriago Delgado
doaj   +1 more source