Results 101 to 110 of about 1,424,659 (349)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Sliding mode control of the automobile electro-coating conveying mechanism with a nonlinear disturbance observer

Advances in Mechanical Engineering, 2018
The trajectory-tracking performance of the automobile electro-coating conveying mechanism is severely interrupted by highly nonlinear crossing couplings, unmodeled dynamics, parameter variation, friction, and unknown external disturbance. In this article,
Wei Yuan, Guoqin Gao
doaj   +1 more source

Current Control with Improved Anti-interference Ability for Grid-connected Inverters [PDF]

, 2015
In order to improve anti-interference ability of current control in the grid-connected inverter, this paper presents a current control method based on the disturbance observer.
Liu, S. (Sijia), Zhuang, S. (Shengxian)
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Robust Observer Design against Disturbance

Journal of the Japan Society for Precision Engineering, Contributed Papers, 2004
Generally, the specifications of the robustness and the disturbance or noise applied to the control system are often provided in frequency domain. The traditional observer design is based on a state space structure in time-domin representation of a linear system.
Akihiro ITO, Masatake SHIRAISHI
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Disturbance observer-based robust tracking control for hypersonic vehicles with T-S disturbance modeling

International Journal of Advanced Robotic Systems, 2016
This article concerns a disturbance observer-based L 1 robust anti-disturbance tracking algorithm for the longitudinal models of hypersonic flight vehicles with different kinds of unknown disturbances.
Yang Yi, Lubing Xu, Hong Shen, Xiangxiang Fan   +3 more
doaj   +1 more source

Extended-State-Observer-Based Chattering Free Sliding Mode Control for Nonlinear Systems With Mismatched Disturbance

IEEE Access, 2018
This paper presents a novel chattering free sliding mode control method for a class of nonlinear systems in the presence of matched disturbance and mismatched disturbance based on an extended state observer.
Sheng-Li Shi, Jian-Xiong Li, Yi-Ming Fang   +2 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source