Results 191 to 200 of about 281,561 (238)

Resolving conformational polymorphism in disulfide-rich peptide drugs. [PDF]

Front Chem
Zhu S, Ge Y, Huang H, Xu M.
europepmc   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Dynamic states of an MHC class I molecule during peptide exchange. [PDF]

Nat Commun
Mitlehner A, Pasos-Trejo AS, Becker M, Lan H, Berg L, Hilal T, Loll B, Kuropka B, Clementi C, Freund C.   +9 more
europepmc   +1 more source

NiH‐Catalyzed Enantio‐ and Regioselective Hydroselenylation of Unactivated Alkenes

Advanced Science, EarlyView.
Nickel‐hydride‐catalyzed enantio‐ and regioselective hydroselenylation of unactivated alkenes provides access to chiral organoselenium compounds. Enantiodetermining Ni–H insertion followed by single‐electron diselenide activation generates selenyl radical.
Hyung‐Joon Kang, Jaehun Kim, Sungwoo Hong   +2 more
wiley   +1 more source

Glutathione-Responsive Disulfiram Delivery from Thiol-Functionalized N-Doped Carbon Nanodots: An in vitro Proof-of-Concept Study. [PDF]

Int J Nanomedicine
Panaei M, Mahani M, Divsar F, Khakbaz F.
europepmc   +1 more source

Printable Piezoresistive Hybrid Hydrogels Based on 2D MoS2 for Flexible Pulse Sensing

Advanced Science, EarlyView.
Hybrid 1T‐MoS2‐based hydrogels are engineered through UV curing and 3D printing to achieve tunable electromechanical properties for wearable sensing. These soft architectures enhance mechanical stability and reproducible piezoresistive responses within the physiological pressure range.
Jenny Flores, Arianna Bertero, Luca Ceseracciu, Daniel Jiménez‐Boland, Sara Domenici, Mattia Bramini, Paola Sánchez‐Moreno, Erica Scarcelli, Domenico Galdiero, Pavel Fedorov, Daniil Karnaushenko, Rossella Sesia, Ignazio Roppolo, Micaela Pozzati, Mattia Spedicati, Nicolò Petrini, Marco Sangermano, Bartolomeo Coppola, Teresa Gatti   +18 more
wiley   +1 more source

The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein. [PDF]

PLoS Pathog
Amano G, Arshad H, Patel Z, Schmitt-Ulms G, Watts JC.   +4 more
europepmc   +1 more source

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

Advanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka, Marian Bienstein, Jonas Berger, Ulrich Schwaneberg   +3 more
wiley   +1 more source

Experimental Detection Methods and Clinical Translational Challenges of Disulfidptosis in Cancer. [PDF]

Cells
Han T, Li R, Wang J, Chu Y, Cai L.
europepmc   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source