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Revisiting Disulfide–Yne and Disulfide–Diazonium Reactions for Potential Direct Modification of Disulfide Bonds in Proteins

The Journal of Organic Chemistry, 2022
To find their potential use in protein research, direct addition of a disulfide compound to alkyne (namely disulfide-yne reaction) and S-arylation with arenediazonium salt (namely disulfide-diazonium reaction) were investigated in aqueous or protic solutions.
Wei-Cheng Hung   +6 more
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Dicubyl Disulfide

Journal of the American Chemical Society, 2002
Dicubyl disulfide (1) has been prepared in six steps from commercially available dimethyl-1,4-cubanedicarboxylate in 47% overall yield. In the final step, the previously unknown cubanethiol 2 was oxidized to disulfide 1. X-ray crystallography for 1 reveals the shortest tetragonal C-S bond on record (1.771 A).
Ronny, Priefer   +9 more
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Thiol–Disulfide Exchange in Signaling: Disulfide Bonds As a Switch

Antioxidants & Redox Signaling, 2013
The major function of disulfide bonds is not only the stabilization of protein structures. Over the last 30 years, a change in perspective took place driven by groundbreaking experiments, which promoted disulfide bonds to central players in essential thiol-disulfide exchange reactions involved in signal transduction, thiol protection, and redox ...
Messens, Joris, Collet, Jean François
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