Results 61 to 70 of about 260,568 (212)

Antibody Conjugates via Disulfide Bridging: Towards therapeutic and diagnostic applications

, 2015
Antibodies play a prominent role in chemical and biological research and the largest application of chemical bioconjugation reagents is in the production of antibody conjugates.
Hull, EA
core  

Disulfide-Cross-Linked Nanogel-Based Nanoassemblies for Chemotherapeutic Drug Delivery

, 2023
Although nanoparticle-based chemotherapeutic strategies have gained in popularity, the efficacy of such therapies is still limited in part due to the different nanoparticle sizes needed to best accommodate different parts of the drug delivery pathway ...
Mina Yeganeh (15502157), Andrew Lofts (15502154), Matthew A. Campea (15502151), Fei Xu (368913), Todd Hoare (1418734), Meghan Kostashuk (15502160)   +5 more
core   +1 more source

Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies

Frontiers in Immunology, 2019
Although it is now possible to produce recombinant HIV envelope glycoproteins (Envs) with epitopes recognized by the 5–6 major classes of broadly neutralizing antibodies (bNAbs), these have failed to consistently stimulate the formation of bNAbs in ...
Jennie M. Hutchinson, Kathryn A. Mesa, David L. Alexander, Bin Yu, Sara M. O'Rourke, Kay L. Limoli, Terri Wrin, Steven G. Deeks, Phillip W. Berman   +8 more
doaj   +1 more source

Disulfide-Mediated Bioconjugation: Disulfide Formation and Restructuring on the Surface of Nanomanufactured (Microfluidics) Nanoparticles

, 2019
This study is about (1) nanomanufacturing (focusing on microfluidic-assisted nanoprecipitation), (2) advanced colloid characterization (focusing on field flow fractionation), and (3) the possible restructuring of surface disulfides.
Benedetto Grimaldi, Arianna Gennari (3932471), Nicola Tirelli (1477183), Mike Geven (1836955), Donghun Koo, Roberto Donno (3752566), Arianna Gennari, Hanying Luo (2619412), Roberto Donno, Nicola Tirelli, Mike Geven, Gangadhar Panambur (6997640), Donghun Koo (6997637), Roberto Marotta (445587), Gangadhar Panambur, Hanying Luo, Benedetto Grimaldi (691553), Roberto Marotta   +17 more
core   +1 more source

Disulfide Bond Formation and Methionine Sulfoxide Reduction in Streptococcus gordonii

, 2019
Disulfide bonds are important for proper folding and activity of extracytoplasmic proteins. These bonds are formed, reduced, and isomerized by thiol-disulfide oxidoreductases (TDORs).
Jalal, Naif
core  

Electrocatalytic Reduction of Disulfide Bonds in Antibodies

In most FDA-approved antibody-drug conjugates, cysteines generated through reduction of the native interchain di-sulfide bonds in monoclonal antibodies (mAbs) are conjugated with maleimide-based cytotoxic payloads.
Cecilia, Bottecchia, Kelly, Raymond, Monica, Haley, Rodell, Barrientos, Yangzhong , Qin, Marion, H., Emmert, Serge, Ruccolo   +6 more
core   +1 more source

Protein disulfide isomerase-9 interacts with the lumenal region of the transmembrane endoplasmic reticulum stress sensor kinase, IRE1, to modulate the unfolded protein response in Arabidopsis

Frontiers in Plant Science
Environmental stressors disrupt secretory protein folding and proteostasis in the endoplasmic reticulum (ER), leading to ER stress. The unfolded protein response (UPR) senses ER stress and restores proteostasis by increasing the expression of ER-resident
Rina Carrillo, Kaela Iwai, Alena Albertson, Gabrielle Dang, David A. Christopher   +4 more
doaj   +1 more source

Solvent Induced Disulfide Bond Formation in 2,5-dimercapto-1,3,4-thiadiazole

, 2007
Disulfide bond formation is the decisive event in the protein folding to determine the conformation and stability of protein. To achieve this disulfide bond formation in vitro, we took 2,5-dimercapto-1,3,4-thiadiazole (DMcT) as a model compound. We found
Palraj Kalimuthu, S. Abraham John, Palanisamy Kalimuthu   +2 more
core  

Structural and Catalytic Roles of the Disulfide Bonds Cys19–Cys154 and Cys134–Cys199 in Trypsin-like Proteases: Evolutionary Insights for Disulfide Bond Acquisition

Molecules
Trypsin is one of the most extensively studied enzymes in biochemistry. However, little information is available on the role of the disulfide bonds to establish the correct conformation and enzyme activity during molecular evolution.
Maiko Minakata, Yuri Murakami, Orika Ashida, Miki Matsuzaki, Kairi Ogawa, Nanako Saeki, Shigeru Shimamoto, Mitsuhiro Miyazawa, Yuji Hidaka, Nana Sakata   +9 more
doaj   +1 more source

Is dynamic thiol/disulfide homeostasis associated with the prognosis of myelodysplastic syndrome? [PDF]

Journal of Medical Biochemistry, 2020
Background: This study planned to investigate the relationship of dynamic thiol/disulfide homeostasis with the prognosis of myelodysplastic syndrome (MDS). Methods: 80 patients who had been diagnosed with MDS between 2012 and 2017 and who were older than
Ali Ucar Mehmet, Tombak Anıl, Dagdas Simten, Akdeniz Aydan, Ceran Funda, Neselioglu Salim, Erel Ozcan, Ozet Gulsum   +7 more
doaj