Results 71 to 80 of about 260,568 (212)

Inhibition of Lactate Dehydrogenase-A by Singlet Oxygen and Hypochlorous Acid via Cysteine Oxidation and Irreversible Conformational Changes

open access: yesBioChem
Muscle lactate dehydrogenase (LDH-A) catalyzes the reduction of pyruvate to lactate, the end product of anaerobic glycolysis. LDH-A is overexpressed in many cancers prior to and even when tumors receive adequate oxygen, and lactate has multiple cellular ...
Lisa Landino, Lydia Boike, Taylor Lain
doaj   +1 more source

Characterising the expression and interactions of the Endoplasmic Reticulum Oxidoreductase Erol β [PDF]

open access: yes, 2006
Proteins destined for the secretory pathway and endoplasmic reticulum (ER) resident proteins are targeted to the ER through an N-terminal signal sequence. Proteins then follow a post-translational maturation process to fold into functional proteins.
Gunasekara, Sanjika Dias
core  

Thiol-Disulfide Balance in Fibromyalgia: A Case-Control Study

open access: yesGalician Medical Journal
Aim. We aimed to examine the thiol-disulfide (SS) balance, a recognized marker of oxidative stress, in fibromyalgia syndrome (FMS). Methods. The study comprised 98 female participants (61 newly diagnosed patients and 37 patients under treatment) with ...
Esra Sahingoz Bakirci   +7 more
doaj   +1 more source

Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs

open access: yes
Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide formats for drug design and discovery as they have the potential to combine the best characteristics of small molecules and proteins.
Hongtan Liu (12244451)   +10 more
core   +1 more source

Lactate Dehydrogenase-B Oxidation and Inhibition by Singlet Oxygen and Hypochlorous Acid

open access: yesOxygen
Alterations in cellular energy metabolism are a hallmark of cancer and lactate dehydrogenase (LDH) enzymes are overexpressed in many cancers regardless of sufficient oxygen and functional mitochondria. Further, L-lactate plays signaling roles in multiple
Lisa M. Landino, Emily E. Lessard
doaj   +1 more source

Novel fluorinated phosphorus–sulfur heteroatom compounds : synthesis and characterization of ferrocenyl- and aryl-phosphonofluorodithioic salts, adducts, and esters

open access: yes, 2015
A series of novel ferrocenyl- and aryl-phosphonofluorodithioic salts, adducts, and esters has been prepared. The reaction of 2,4-diferrocenyl-1,3,2,4-diathiadiphosphetane 2,4-disulfide {[FcP(μ-S)S]2, FcLR} with dry KF or tetrabutylammonium fluoride (TBAF)
Junyi Du   +12 more
core   +1 more source

Discovery of a Novel Insecticidal Peptide with a Cystine-Stabilized α-Helix/α-Helix Motif from the Venom of Scorpion Liocheles australasiae

open access: yesMolecules
Scorpion venom contains various bioactive peptides, many of which exhibit insecticidal activity. The majority of these peptides have a cystine-stabilized α-helix/β-sheet (CSαβ) motif. In addition to these peptides, scorpion venom also contains those with
Masahiro Miyashita   +4 more
doaj   +1 more source

Occupational exposure to carbon-disulfide [PDF]

open access: yes
"The recommended standard is given limiting employee exposure to less than 3 milligrams per cubic meter of air (1ppm) as a time weighted average concentration for up to a 10 hour work shift in a 40 hour workweek or less than 30 milligrams per cubic meter

core   +1 more source

The role of thiol-disulfide homeostasis in gouty arthropathy

open access: yesUlusal Romatoloji Dergisi
Objective: Gout, the most common form of crystal-induced arthritis, is characterized by the accumulation of monosodium urate crystals within the joints.
Sevinç Can Sandıkçı   +4 more
doaj   +1 more source

Synthesis of a resin monomer-soluble polyrotaxane crosslinker containing cleavable end groups

open access: yesBeilstein Journal of Organic Chemistry, 2014
A resin monomer-soluble polyrotaxane (PRX) crosslinker with cleavable end groups was synthesized to develop degradable photosetting composite resins. The PRX containing 50 α-cyclodextrins (α-CDs) with disulfide end groups was initially modified with n ...
Ji-Hun Seo   +3 more
doaj   +1 more source

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