Results 191 to 200 of about 96,012 (310)

Microfluidic Electrochemical Biosensor for the Detection of Platelet Factor 4 Antibody‐Mediated Thrombotic Disorders

Advanced Science, EarlyView.
A microfluidic electrochemical biosensor enables sensitive and specific detection of antibodies associated with vaccine‐induced immune thrombotic thrombocytopenia (VITT) and heparin‐induced thrombocytopenia (HIT). The platform uses two antigen targets— platelet factor 4 (PF4) and cross‐linked‐PF4 (c‐PF4)—and microliter volumes of patient sera to ...
Diana F. Cedillo‐Alcantar, Adam Kanack, Seonhwa Lee, Alan M. Gonzalez‐Suarez, Kihak Gwon, Emily Mauch, Thi Thanh‐Qui Nguyen, Anand Padmanabhan, Alexander Revzin   +8 more
wiley   +1 more source

Molecular Basis of Interchain Disulfide Bond Formation in BMP-9 and BMP-10. [PDF]

J Mol Biol
Schwartze TA, Morosky SA, Rosato TL, Henrickson A, Lin G, Hinck CS, Taylor AB, Olsen SK, Calero G, Demeler B, Roman BL, Hinck AP.   +11 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Preformed mincle dimers stabilized by an interchain disulfide bond in the neck region. [PDF]

Glycobiology
Liu Y, Drickamer K, Taylor ME.
europepmc   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Polysulfides promote protein disulfide bond formation in microorganisms growing under anaerobic conditions. [PDF]

Appl Environ Microbiol
Xin Y, Wang Q, Yang J, Wu X, Xia Y, Xun L, Liu H.   +6 more
europepmc   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Disulfide Bond Engineering of Soluble ACE2 for Thermal Stability Enhancement. [PDF]

Int J Mol Sci
Kim YS, Kim M, Park HM, Kim HJ, Ryu SE.
europepmc   +1 more source

Restoration of structural stability and ligand binding after removal of the conserved disulfide bond in tear lipocalin

, 2014
Oktay K. Gasymov, Adil R. Abduragimov, Ben J. Glasgow   +2 more
openalex   +1 more source

On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

, 2020
Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Peifeng Tang, Laurel Hoffman, June Kuang, Peiran Liu, Chao Huang, Cheng Du, Liyuan Tao, Letha Chemmalil, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu   +14 more
openalex   +1 more source