Results 101 to 110 of about 14,560 (215)

Structural and Functional Characterisation of a Metagenome‐Derived CYP108D18 Reveals an Unusual Dioxygen‐Bound State and Selective Hydrocarbon Hydroxylation

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
CYP108D18, identified from a hot spring metagenome, catalyses selective phenylcyclohexane hydroxylation. This P450 has an exceptionally low substrate‐bound heme redox potential. Crystal structures revealed an unusual dioxygen‐bound substrate‐free form and a persistent open active site upon substrate binding.
Simran Kundral, Peter D. Giang, Alicia M. Kirk, Julia B. Buczynski, Kasun S. A. Arachchige, Sunil K. Khare, Paul V. Bernhardt, Paul N. Evans, Luke W. Guddat, Stephen G. Bell, James J. De Voss   +10 more
wiley   +1 more source

Sex‐Specific Neurogenic and Cognitive Responses in a Murine Model of Accelerated Aging

Aging Cell, Volume 25, Issue 10, October 2026.
Male and female SAMP8 mice exhibit different physiological and pathological trajectories of hippocampal neurogenesis despite exhibiting similar cognitive performance. ER272 treatment was associated with improved cognition and enhanced neurogenesis exclusively in males highlighting the importance of sex‐specific analysis.
Ricardo Gómez‐Oliva, Andrea Chamorro‐Francisco, Isabel Atienza‐Navarro, Livia Carrascal, María D. Freire‐Aragón, Rosario Hernández‐Galán, Pedro Nunez‐Abades, Mónica García‐Alloza, Carmen Castro   +8 more
wiley   +1 more source

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

Mass Spectrometric Studies of Diterpenes. 7. Aromatic Diterpenes. [PDF]

Acta Chemica Scandinavica, 1970
C. R. Enzell, I. Wahlberg, Synnøve Liaaen-Jensen, Dagny Holme, Aud Lamvik, Erling Sunde, Nils Andreas Sørensen   +6 more
openaire   +1 more source

Terpenoids, flavonoids and other constituents of Eupatorium betonicaeforme (Asteraceae)

Journal of the Brazilian Chemical Society, 2006
A new acylated kaurene diterpene, characterized as 15alpha-decanoyloxy-kaur-16-en-19-oic acid, along with nine known compounds: pentacosanoic acid, 24alpha-ethyl-5alpha-cholesta-7,22E-dien-3beta-ol, 15alpha-hydroxy-kaur-16-en-19-oic acid, 8beta ...
Albuquerque Maria Rose Jane R., Pires Andreza Maria L., Pessoa Otília Deusdênia L., Silveira Edilberto R.   +3 more
doaj  

Dietary modulation of antimicrobial peptides (HAMP and LEAP2) in Chinook salmon (Oncorhynchus tshawytscha) fed a phytobiotic functional diet: Integrated genomic characterisation and tissue‐specific expression

Journal of Fish Biology, Volume 109, Issue 4, Page 1978-1990, October 2026.
Abstract Antimicrobial peptides (AMPs) are key components of the innate immune system in fish, providing rapid protection against microbial pathogens. Among these, the liver‐expressed antimicrobial peptides (LEAPs), comprising LEAP‐1 (hepcidin; HAMP) and LEAP‐2, play central roles in host defence and iron regulation.
Roberta Marcoli, Jane E. Symonds, Seumas P. Walker, Cesar Lopez, Mark A. Preece, Christopher Battershill, Steve Bird   +6 more
wiley   +1 more source

Divergent roles of ent‐kaurene oxidase paralogs in rice momilactone biosynthesis

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3776-3789, October 2026.
Rice contains a five‐gene tandem array of genes encoding members of the ent‐kaurene oxidase (KO) family, with OsKOL4 and OsKOL5 playing divergent roles in momilactone metabolism, but both acting in the production of antifungal and antibacterial phytoalexins, which are important for disease resistance.
Zhibiao Wang, Yiling Feng, Leiming You, Meimei Xu, Kristin Helwig, Riqing Li, Si Nian Char, Bing Yang, Reuben J. Peters   +8 more
wiley   +1 more source

Sequence-guided engineering of a bacterial diterpene synthase induces further cyclization. [PDF]

ACS Catal
Wei X, Ning W, Huang PS, Nafie J, Ghiviriga I, Rudolf JD.   +5 more
europepmc   +1 more source

Cafestol and kahweol: coffee diterpenes with trypanocidal activity and cardioprotective effects. [PDF]

Front Cell Infect Microbiol
Barbosa JMC, Simões BM, Novaes FJM, da Silva MAE, da Silva PB, de Aquino Neto FR, de Rezende CM, Salomão K, de Melo TG.   +8 more
europepmc   +1 more source

Diterpenes with Abietane and Clerodane Skeletons from the Mexican <i>Salvia</i> Species as Potential Bioactive Compounds. [PDF]

Molecules
Ortiz-Mendoza N, Bazany-Rodríguez IJ, Martínez-Gordillo MJ, Basurto-Peña FA, Dorazco-González A, Fragoso-Martínez I, González-Trujano ME, Martínez Ambriz E, Soto-Hernández M, Aguirre-Hernández E.   +9 more
europepmc   +1 more source