Results 161 to 170 of about 14,931,309 (280)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Effects of Post-Divergence Gene Flow on Simultaneous Divergence Time Testing. [PDF]

Mol Ecol Resour
Tofflemire MA, Burns KJ, Sukumaran J.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Integrated analysis of fossils and molecular divergence time estimates a latest Jurassic origin of angiosperms. [PDF]

Nat Plants
Wu R, Álvarez-Carretero S, Tong Y, Wan S, Schneider H, Clark J, Pisani D, Silvestro D, Donoghue PCJ.   +8 more
europepmc   +1 more source

PAReTT: A Python Package for the Automated Retrieval and Management of Divergence Time Data from the TimeTree Resource for Downstream Analyses. [PDF]

J Mol Evol, 2023
Le Clercq LS, Kotzé A, Grobler JP, Dalton DL.   +3 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Comparative genomics, phylogenomic reconstruction and divergence time analysis of 32 <i>Delphinium</i> species based on complete chloroplast genomes. [PDF]

Front Plant Sci
Lv T, Zhang Y, Guo L, Hu X, Ju J, Tang N.   +5 more
europepmc   +1 more source

Phylogenetic diversity of eastern Asia-eastern North America disjunct plants is mainly associated with divergence time. [PDF]

Plant Divers, 2023
Lin HY, Sun M, Hao YJ, Li D, Gitzendanner MA, Fu CX, Soltis DE, Soltis PS, Zhao YP.   +8 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Molecular Phylogeny, Divergence Time Estimation, and Biogeography of <i>Moelleriella</i> (Clavicipitaceae, Hypocreales) with Taxonomic Insights. [PDF]

Biology (Basel)
Lin Y, Yang J, Keyhani NO, Wang L, Yao Y, Wei X, Song F, Qiu Z, Cai S, Guan X, Zhao L, Qiu J.   +11 more
europepmc   +1 more source