Results 191 to 200 of about 34,067 (234)
Concept-driven strategies in target-oriented synthesis. [PDF]
Beilstein J Org ChemChen DY, Li C, Tang Y.
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Chemical Record, 2008
AbstractDiversity‐oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what can be achieved using the DOS approach to library generation.
David R Spring, Mónica Díaz-Gavilán
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AbstractDiversity‐oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what can be achieved using the DOS approach to library generation.
David R Spring, Mónica Díaz-Gavilán
exaly +3 more sources
Diversity-Oriented Asymmetric Synthesis
Synthesis, 2014The application of small molecules to modulate proteins by direct interactions has evolved as a powerful tool for the study of complex biological systems. Conventional genetic approaches have examined biological systems by generating random mutations which were then screened in search of a precise cellular phenotype.
Chandramohan Bathula +2 more
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A Planning Strategy for Diversity‐Oriented Synthesis
Angewandte Chemie International Edition, 2003AbstractIn contrast to target‐oriented synthesis (TOS) and medicinal or combinatorial chemistry, which aim to access precise or dense regions of chemistry space, diversity‐oriented synthesis (DOS) populates chemical space broadly with small‐molecules having diverse structures.
Martin D, Burke, Stuart L, Schreiber
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Diversity-Oriented Synthesis of Steviol Glycosides
The Journal of Organic Chemistry, 2018With cheap and easily available mixtures of steviol glycosides as starting materials, a practical method for steviol acquisition has been developed, on the basis of which a facile, diversity-oriented, and economic protocol for the synthesis of structurally defined steviol glycosides was established.
Zhi Qiao +6 more
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Diversity-Oriented Synthesis of Chromenes
2023Diversity-oriented synthesis (DOS) plays an important role in the construction of various natural products and the development of diverse small molecules of biological significance. In recent years, numerous diversity-oriented approaches have been demonstrated to furnish complex structures with molecular diversity from readily accessible starting ...
Atul Kumar +3 more
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Diversity-Oriented Synthesis of Kröhnke Pyridines
Journal of Combinatorial Chemistry, 2009An efficient reagent-controlled approach for the regiospecific synthesis of new 2,2'-bipyridine derivatives in high-temperature water via microwave-assisted multicomponent reactions of aldehydes, 3-aryl-3-oxopropanenitrile, 2-acetylpyridine, and ammonium acetate is reported.
Bo, Jiang +4 more
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Current strategies for diversity-oriented synthesis
Current Opinion in Chemical Biology, 2010Compounds accessed through diversity-oriented synthesis (DOS) are showing promise in modulating the activities of several targets that are currently considered 'undruggable'. Recently many new DOS pathways have been developed employing multi-component reactions, cycloadditions, ring-closing metathesis and tandem processes. Functional group pairing and '
Sivaraman, Dandapani +1 more
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Diversity Oriented Synthesis of Metal-Organic Frameworks
2023Metal-Organic Frameworks (MOFs) are an emerging class of novel porous materials bearing unique high surface area and structural tunability. Post-synthetic functionalization plays a pivotal role not only in facilely diversifying MOF structures but also in meeting the requirement in practical applications.
Hsu, Yu-Chuan +4 more
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Carbohydrates in diversity-oriented synthesis: challenges and opportunities
Organic & Biomolecular Chemistry, 2016Carbohydrates are attractive building blocks for diversity-oriented synthesis due to their stereochemical diversity and high density of polar functional groups.
LENCI, ELENA +2 more
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