Results 201 to 210 of about 34,067 (234)

Synthesis of Privileged Scaffolds by Using Diversity‐Oriented Synthesis

Chemistry – An Asian Journal, 2013
AbstractAn elegant reagent‐controlled strategy has been developed for the generation of a diverse range of biologically active scaffolds from a chiral bicyclic lactam. Reduction of the chiral lactam with LAH or alkylation with LHMDS to trigger different cyclization reactions have been shown to generate privileged scaffolds, such as pyrrolidines ...
Ramu, Surakanti, Sumalatha, Sanivarapu, Chiranjeevi, Thulluri, Pravin S, Iyer, Raghuram S, Tangirala, Rambabu, Gundla, Uma, Addepally, Y L N, Murthy, Lakshmi, Velide, Subhabrata, Sen   +9 more
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Diversity Oriented Synthesis

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
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Diversity-oriented synthesis; a spectrum of approaches and results

Organic & Biomolecular Chemistry, 2008
Since our emerging area article, diversity-oriented synthesis (DOS), which aims to prepare efficiently collections of skeletally diverse small molecules, has developed in the synthetic approaches it employs. This article describes three general strategies, highlighting some successful examples. The utility of DOS, in the interrogation of chemical space
Richard J, Spandl, Andreas, Bender, David R, Spring   +2 more
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Enriching Chemical Space with Diversity‐Oriented Synthesis

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gemma L, Thomas, Emma E, Wyatt, David R, Spring   +2 more
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Diversity-Oriented Synthesis of Polycyclic Diazinic Scaffolds

Organic Letters, 2012
An efficient and versatile synthesis of a polycyclic diazinic system starting from oxazine has been developed using a two-step Michael/retro Michael and cyclization sequence. The substrates were synthesized with good to high yields giving rapid access to molecular diversity.
Nicolas, Gigant, Elise, Claveau, Pascal, Bouyssou, Isabelle, Gillaizeau   +3 more
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Diversity-oriented synthesis of bicyclic and tricyclic alkaloids

Chem. Commun., 2010
A diversity-oriented synthesis involving a cascade sequence, taking linear aminoalkenes to polycyclic scaffolds reminiscent of natural alkaloids, is presented.
Mónica, Díaz-Gavilán, Warren R J D, Galloway, Kieron M G, O'Connell, James T, Hodkingson, David R, Spring   +4 more
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Diversity‐Oriented Synthesis of Morpholine‐Containing Molecular Scaffolds

Chemistry – A European Journal, 2009
Couple and cyclize: A coupling–cyclization strategy employing building blocks from the chiral pool was applied for the generation of morpholine-containing scaffolds (see scheme). The modulation of both the reaction conditions and the stereochemistry of the building blocks allowed the first degree of skeletal diversity, followed by functional group ...
LALLI, CLAUDIA, TRABOCCHI, ANDREA, SLADOJEVICH, FILIPPO, MENCHI, GLORIA, GUARNA, ANTONIO   +4 more
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Diversity-Oriented Synthesis of Bioactive Azaspirocycles

Tetrahedron, 2019
Abstract A collection of novel azaspirocyclic β-arylethylamines was prepared in good yield and excellent diastereoselectivity by an expedient strategy that features condensation of a cyclic ketone with an amino allylsilane and a tandem aza-Sakurai cyclization to generate several different spirocyclic N-heterocycles.
Lance T. Lepovitz, Stephen F. Martin
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Diversity Oriented Synthesis: A Challenge for Synthetic Chemists

2006
This article covers the diversity-oriented synthesis (DOS) of small molecules in order to generate a collection of pure compounds that are attractive for lead generation in a phenotypic, high-throughput screening approach useful for chemical genetics and drug discovery programmes.
A, Bender, S, Fergus, W R J D, Galloway, F G, Glansdorp, D M, Marsden, R L, Nicholson, R J, Spandl, G L, Thomas, E E, Wyatt, R C, Glen, D R, Spring   +10 more
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Diversity‐Oriented Synthesis

2013
Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways.
TRABOCCHI, ANDREA, Stuart L. Schreiber, Kieron M. G. O’Connell, Warren R. J. D. Galloway, David R. Spring, John M. Knapp, Mark J. Kurth, Jared T. Shaw, Ashkaan Younai, Giovanni Muncipinto, Ohyun Kwon, Zhiming Wang, Matthew G. LaPorte, John R. Goodell, Sammi Tsegay, Peter Wipf, Viktor Krchňák, Nadĕžda Cankařová, Eric Marsault, Mark Dow, Francesco Marchetti, Adam Nelson, José Luis Medina Franco, Luca Mannocci, Eduard A. Sergienko, Susanne Heynen Genel, Hongyan Sun, CAVALIERI, DUCCIO, Carlotta De Filippo, Irene Stefanini, Jürgen Bajorath, Jeremy R. Duvall, Eamon Comer, Sivaraman Dandapani, Nicholas Hill, Lingyan Du, Qiu Wang   +36 more
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