Results 221 to 230 of about 5,221,708 (260)
Some of the next articles are maybe not open access.
Current strategies for diversity-oriented synthesis
Current Opinion in Chemical Biology, 2010Compounds accessed through diversity-oriented synthesis (DOS) are showing promise in modulating the activities of several targets that are currently considered 'undruggable'. Recently many new DOS pathways have been developed employing multi-component reactions, cycloadditions, ring-closing metathesis and tandem processes. Functional group pairing and '
Sivaraman, Dandapani +1 more
openaire +2 more sources
Diversity-Oriented Synthesis of Kröhnke Pyridines
Journal of Combinatorial Chemistry, 2009An efficient reagent-controlled approach for the regiospecific synthesis of new 2,2'-bipyridine derivatives in high-temperature water via microwave-assisted multicomponent reactions of aldehydes, 3-aryl-3-oxopropanenitrile, 2-acetylpyridine, and ammonium acetate is reported.
Bo, Jiang +4 more
openaire +2 more sources
Carbohydrates in diversity-oriented synthesis: challenges and opportunities
Organic & Biomolecular Chemistry, 2016Carbohydrates are attractive building blocks for diversity-oriented synthesis due to their stereochemical diversity and high density of polar functional groups.
LENCI, ELENA +2 more
openaire +3 more sources
Synthesis of Privileged Scaffolds by Using Diversity‐Oriented Synthesis
Chemistry – An Asian Journal, 2013AbstractAn elegant reagent‐controlled strategy has been developed for the generation of a diverse range of biologically active scaffolds from a chiral bicyclic lactam. Reduction of the chiral lactam with LAH or alkylation with LHMDS to trigger different cyclization reactions have been shown to generate privileged scaffolds, such as pyrrolidines ...
Ramu, Surakanti +9 more
openaire +2 more sources
Diversity Oriented Synthesis of Metal-Organic Frameworks
2023Metal-Organic Frameworks (MOFs) are an emerging class of novel porous materials bearing unique high surface area and structural tunability. Post-synthetic functionalization plays a pivotal role not only in facilely diversifying MOF structures but also in meeting the requirement in practical applications.
Hsu, Yu-Chuan +4 more
openaire +2 more sources
Enriching Chemical Space with Diversity‐Oriented Synthesis
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gemma L, Thomas +2 more
openaire +2 more sources
Diversity-oriented synthesis; a spectrum of approaches and results
Organic & Biomolecular Chemistry, 2008Since our emerging area article, diversity-oriented synthesis (DOS), which aims to prepare efficiently collections of skeletally diverse small molecules, has developed in the synthetic approaches it employs. This article describes three general strategies, highlighting some successful examples. The utility of DOS, in the interrogation of chemical space
Richard J, Spandl +2 more
openaire +2 more sources
Diversity-oriented synthesis of bicyclic and tricyclic alkaloids
Chem. Commun., 2010A diversity-oriented synthesis involving a cascade sequence, taking linear aminoalkenes to polycyclic scaffolds reminiscent of natural alkaloids, is presented.
Mónica, Díaz-Gavilán +4 more
openaire +2 more sources
Diversity-Oriented Synthesis of Polycyclic Diazinic Scaffolds
Organic Letters, 2012An efficient and versatile synthesis of a polycyclic diazinic system starting from oxazine has been developed using a two-step Michael/retro Michael and cyclization sequence. The substrates were synthesized with good to high yields giving rapid access to molecular diversity.
Nicolas, Gigant +3 more
openaire +2 more sources