Results 91 to 100 of about 18,876 (219)

Molecular Mechanisms and Therapeutic Applications of Extracellular Vesicles in Remodeling of the Skin Cancer Niche

Nano Select, Volume 7, Issue 9, September 2026.
Extracellular vesicles at the nexus of skin cancer progression and precision therapy. EVs orchestrate tumor microenvironment remodeling through cargo‐mediated intercellular communication, immune modulation, angiogenesis, and extracellular matrix reorganization, while also emerging as next‐generation platforms for targeted drug delivery, biomarker ...
Megha Kotian, Maria Nison, Deepanjan Datta, Soniya Kumbham, Namdev Dhas, Praveen Halagali, Vasudev R Pai, Vamshi Krishna Tippavajhala   +7 more
wiley   +1 more source

Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.

PLoS ONE, 2014
ObjectivesDickkopf-1 (DKK1) is a potent inhibitor of Wnt signalling, which exerts anabolic effects on bone and also takes part in the regulation of vascular cells. Our aims were to evaluate serum DKK1 in type 2 diabetes (T2DM) patients and to analyze its
Antonia Garcia-Martín, Rebeca Reyes-Garcia, Beatriz García-Fontana, Sonia Morales-Santana, Ana Coto-Montes, Manuel Muñoz-Garach, Pedro Rozas-Moreno, Manuel Muñoz-Torres   +7 more
doaj   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, Volume 59, Issue 9, September 2026.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Inflammation‐Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF‐κB Crosstalk

International Endodontic Journal, Volume 59, Issue 9, Page 1743-1759, September 2026.
ABSTRACT Background Inflammation critically determines dental pulp regenerative outcomes, with dental pulp stem cells (DPSCs) orchestrating tissue homeostasis through differentiation, self‐renewal and immunomodulation processes dynamically regulated by Wnt/β‐catenin and NF‐κB signaling crosstalk.
V. Rajasekar, M. Huang, M. M. Abdalla, P. Neelakantan, C. K. Y. Yiu   +4 more
wiley   +1 more source

DataSheet1_Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of Dickkopf-1 (DKK1).docx

, 2021
WNT signaling pathway inhibitor Dickkopf-1 (DKK1) is related to cancer progression; however, its diagnostic and prognostic potential have not been investigated in a pan-cancer perspective.
Ye Jin (286793), Hongmei Zhang (179574), Shuang Gao (517049)   +2 more
core   +1 more source

Patient‐Derived iPSC‐MSC Modelling Reveals Reversible GSK3‐Mediated Suppression of Mesenchymal Lineage Differentiation in Legg‐Calvé‐Perthes Disease

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Legg‐Calvé‐Perthes disease (LCPD) is an idiopathic paediatric osteonecrosis characterized by avascular injury to the femoral head, resulting in structural collapse and early osteoarthritis. Although mesenchymal stem cell (MSC) dysfunction has been implicated, the underlying mechanisms remain unclear due to the absence of human disease models ...
Binna Seol, Hyung Jin Lim, Cho Lok Song, Jungwoon Lee, Yee Sook Cho   +4 more
wiley   +1 more source

Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease

Molecular Medicine
Background The current treatment of osteogenesis imperfecta (OI) is imperfect. Our study thus delves into the potential of using Dickkopf-1 antisense (DKK1-AS) to treat OI. Methods We analysed serum DKK1 levels and their correlation with lumbar spine and
Jih-Yang Ko, Feng-Sheng Wang, Wei-Shiung Lian, Fu-Shine Yang, Jeng-Wei Chen, Po-Hua Huang, Chin-Yi Liao, Shu-Jui Kuo   +7 more
doaj   +1 more source

Post-natal Effect of Overexpressed DKK1 on Mandibular Molar Formation

, 2011
Dickkopf-related protein 1 (DKK1) is a potent inhibitor of Wnt/β-catenin signaling. Dkk1-null mutant embryos display severe defects in head induction.
T. Gao, X.L. Han, M. Liu, A. Voisey, P. Dechow, L. Tefera, H.Z. Ke, Y.S. Ren, P. Kurimoto, J.Q. Feng   +9 more
core   +1 more source

Omega Fatty Acids in Hair Loss Disorders: A Scoping Review of Preclinical and Clinical Evidence

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Omega fatty acids, including polyunsaturated omega‐3 and omega‐6 fatty acids (PUFAs) and monounsaturated omega‐9 fatty acids, regulate inflammation, cellular signaling, and tissue homeostasis, and may influence hair follicle biology and hair growth.
Nana‐Hawwa Abdul‐Rahman, Jacqueline D. Wang, Miriam Motlak, Gerardo Guiltarte, Reethi S. Padmanabhan, Ellen T. Lee, Sonal Choudhary   +6 more
wiley   +1 more source

Transcriptomic Profiling of Canine Mammary Tumours Reveals Significant Heterogeneity Between and Within Histological Classes

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 444-457, September 2026.
ABSTRACT This study presents a comprehensive transcriptomic analysis of 128 canine mammary tumours (CMTs), aiming to characterize their molecular landscape. Differential gene expression analysis (DGE), gene set enrichment analysis (GSEA) and clustering based on the human PAM50 gene panel were applied to explore molecular differences between the ...
Ingrid Marie Moberg, Nina Hansen, Helga Bergholtz, Kaja Sverdrup Borge, Gjermund Gunnes, Ellen Frøysadal Arnet, Ole Albert Guttersrud, Monica Hongrø Solbakken, Frode Lingaas   +8 more
wiley   +1 more source