Results 101 to 110 of about 18,876 (219)
, 2016 Introducción: El objetivo del estudio es evaluar la relación entre la carga inflamatoria, el riesgo cardiovascular y el metabolismo óseo en pacientes con artritis reumatoide que inician tratamiento con terapia biológica.
Reyes-García R +6 more
core
Advances in therapeutic approaches to gastric cancer
CA: A Cancer Journal for Clinicians, Volume 76, Issue 5, September/October 2026.Abstract Gastric cancer remains a leading cause of cancer‐related mortality worldwide, with nearly 1 million new cases diagnosed annually. Despite innovations in diagnosis, most patients still present at advanced stages, contributing to a poor prognosis.
Feng Wang +9 more
wiley +1 more source
DKK1 inhibits proliferation and migration of prostate cancer cells.
, 2013 (A) Tritiated thymidine incorporation in PC3 cultures in the absence or presence of Wnt3a or DKK1. While high concentration of Wnt3a (10nM) enhanced PC3 cell proliferation, DKK1 inhibited PC3 proliferation in a dose-dependent manner.
Wei-Qiang Gao (200112) +4 more
core +1 more source
DKK1 eukaryotic expression plasmid and expression product identification
Genetics and Molecular Research, 2015 We constructed the human dickkopf 1 (DKK1) eukaryotic expression plasmid and expressed, purified, and identified its expression product. We extracted cancer cells from cervical cancer tissue, followed by extraction of mRNA. Reverse transcription-polymerase chain reaction was conducted to obtain DKK1 gene fragments.
G Y, Bao, K Y, Lu, S F, Cui, L, Xu
openaire +2 more sources
Dkk1 activity defines the ANE territory by antagonizing Wnt signaling.
, 2013 (A) qPCR measurements from three different batches of embryos showing the number of Dkk1 transcripts/embryo at the indicated stages during early development. Values were normalized to z12 transcripts (see Materials and Methods). (B) In situ hybridization
Ryan C. Range (103325) +2 more
core +1 more source
Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools [PDF]
, 2019 Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous studies have emerged implicating Dkk1 in various malignancies and neurodegenerative diseases through an unknown mechanism.
Giger, Florence A.; id_orcid +3 more
core +1 more source
Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse
Mechanisms of Development, 2007 Mouse embryos lacking Gsc and Dkk1 function display severe deficiencies in craniofacial structures which are not found in either Dkk1 homozygous null or Gsc homozygous null mutant embryos. Loss of Gsc has a dosage-related effect on the severity of head truncation phenotype in Dkk1 heterozygous embryos.
Lewis, Samara L. +8 more
openaire +2 more sources
DKK1's Potential Role As A Biomarker In Pancreatic Adenocarcinoma
, 2018 Dickkopf-1 (Dkk1)’s dysregulation has been implicated in the pathogenesis of a variety of cancers. It is part of the Dkk family of proteins that includes Dkk2, Dkk3 and Dkk4.
Igbinigie, Eseosaserea Grace
core
DKK1 promoter methylation in MM cell lines.
, 2012 (A) Total RNA was isolated and RT–PCR analyses were performed with the specific primers indicated. Complementary DNA from prostate cancer cell line (PC-3) was used as positive control (PC) for DKK1 expression. The β-actin expression was used as a loading
Richard W. J. Groen (182567) +6 more
core +1 more source
Journal of DiabetesBackground Dickkopf1 (DKK1) is a protein with established links to metabolic diseases. However, its association with polycystic ovary syndrome (PCOS) and insulin resistance (IR) remains ambiguous.
Jiaxiu Ling +9 more
doaj +1 more source