Results 81 to 90 of about 18,876 (219)

A beneficial effect of a novel DKK1 monoclonal antibody and its sequential alendronate on bone and muscle properties of orchiectomized mice

Journal of Orthopaedic Translation
Background: Insights into basic bone biology and genetic disorders have led to advances in the treatment of osteoporosis. However, new drugs for the treatment of osteoporosis in men remain insufficient.
Yanye Wang, Lei Sun, Lingyang Meng, Bingna Zhou, Dapeng Zhang, Weizhu Qian, Lijia Cui, Qian Zhang, Ou Wang, Yan Jiang, Weibo Xia, Xiaoping Xing, Mei Li   +12 more
doaj   +1 more source

Expression of DKK1 in human NSCLC cell lines.

, 2013
(A) Expression of DKK1 on mRNA level (RT-PCR: 28 cycles of amplification). GAPDH mRNA was used as the internal control. (B) Expression of DKK1 on protein level. β-actin was used as the internal control.
Shujun Li (176557), Baoen Shan (442100), Airong Cui (504836), Xuebo Qin (504835), Sen Wei (103178), Xiaolu Wang (504838), Xin Guo (123593), Yuzheng He (504837)   +7 more
core   +1 more source

Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation [PDF]

, 2010
SummaryParathyroid hormone (PTH) suppresses Dickkopf 1 (Dkk1) expression in osteoblasts. To determine whether this suppression is essential for PTH-mediated Wnt signaling and bone formation, we examined mice that overexpress Dkk1 in osteoblasts (Dkk1 ...
Yang, Dehong, Thomas, Clare C., Schipani, Ernestina, Bringhurst, F. Richard, Saito, Hiroaki, Kuhstoss, Stuart A., Galvin, R.J. Sells, Kronenberg, Henry M., Baron, Roland, Guo, Jun, Liu, Minlin, Bouxsein, Mary L.   +11 more
core   +1 more source

Elevated DKK1 expression distinguishes basal-like human breast cancer.

, 2022
Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4).
Shahan Mamoor
core   +1 more source

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

Obesity Reviews, Volume 27, Issue 10, October 2026.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel   +6 more
wiley   +1 more source

Dynamic Remodeling of Oocyte‐Granulosa Cell Communication During Bovine Folliculogenesis Revealed by Transcriptomic Meta‐Analyses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Bidirectional communication between oocytes and granulosa cells undergoes progressive remodeling during bovine folliculogenesis. Integrative transcriptomic analysis identified stage‐specific ligand‐receptor signaling networks coordinating structural, metabolic, and developmental processes.
Noemi Monferini, Ludovica Donadini, Pritha Dey, Federica Franciosi, Valentina Lodde, Maria Belen Rabaglino, Alberto Maria Luciano   +6 more
wiley   +1 more source

Effects of DKK1 knockdown in LTEP-a-2 cell.

, 2013
(A) RT-PCR and Western blot analysis of the DKK1 expression. DKK1 level in LTEP-a-2 cell transfected with pSilencer-DKK1 is significantly lower than that in pSilencer-NC and blank control group. (B) The wounded and healing LTEP-a-2 cells. (C) Measurement
Shujun Li (176557), Baoen Shan (442100), Airong Cui (504836), Xuebo Qin (504835), Sen Wei (103178), Xiaolu Wang (504838), Xin Guo (123593), Yuzheng He (504837)   +7 more
core   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1

Cellular & Molecular Biology Letters, 2019
Background This study aimed to investigate the effects of miR-613 on the proliferation, invasion and apoptosis of rheumatoid arthritis synovial fibroblasts (RASFs). Methods Synovial tissue samples were collected from 20 rheumatoid arthritis (RA) patients
Liang Liu, Yanhua Zuo, Yan Xu, Zongfang Zhang, Ying Li, Jie Pang   +5 more
doaj   +1 more source

DKK1 and Kremen Expression Predicts the Osteoblastic Response to Bone Metastasis

Translational Oncology, 2018
Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic ...
Katrina L. Clines, Gregory A. Clines
doaj   +1 more source