Results 61 to 70 of about 18,876 (219)

Characterisation of human hair follicle development

Journal of Anatomy, EarlyView.
Schematic of hair follicle development in human skin. Hair follicle primordia of similar sizes, but different densities, are laid out across the skin. The distinction between terminal and vellus hair sites is not obvious at early stages of hair follicle development.
Zoe R. Sudderick, James D. Glover, Cameron Batho‐Samblas, Barbara Bo‐Ju Shih, Denis J. Headon   +4 more
wiley   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

Effect and mechanism of Dickkopf-related protein 1 on urinary sodium excretion in spontaneously hypertensive rats

Di-san junyi daxue xuebao, 2020
Objective To explore the role of Dickkopf-related protein 1 (DKK1) in hypertension and its effect on urinary sodium excretion. Methods Twelve rats with normal blood pressure (Wister Kyoto rats, WKY), and 12 primary hypertension rats (spontaneously ...
CHENG Fangling, CHENG Fangling, WANG Hongyong, YANG Yongjian   +3 more
doaj   +1 more source

Leishmania major-derived lipophosphoglycan influences the host’s early immune response by inducing platelet activation and DKK1 production via TLR1/2

Frontiers in Immunology, 2023
BackgroundPlatelets are rapidly deployed to infection sites and respond to pathogenic molecules via pattern recognition receptors (TLR, NLRP). Dickkopf1 (DKK1) is a quintessential Wnt antagonist produced by a variety of cell types including platelets ...
Olivia C. Ihedioha, Anutr Sivakoses, Stephen M. Beverley, Diane McMahon-Pratt, Alfred L. M. Bothwell   +4 more
doaj   +1 more source

The effect of 1,25(OH)2D3 on Dickkopf-1 methylation in colorectal cancer

Clinical Epigenetics
Background Vitamin D is a fat-soluble vitamin that has a protective role in colorectal cancer. Several studies have identified the association between vitamin D and changes in DNA methylation in different types of tumours.
Hongyan Sun, Liehao Yang, Nan Li, Yue Hu, Qianying Hu, Zilong Zhou, Xianling Cong   +6 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Overexpression and silencing of DKK1 in SW480 cells.

, 2012
pCMV vector containing human DKK1 gene was used to transfect cells before sample collection for analysis. Empty pCMV vector was used as the control for the overexpression experiments. Three independent cell samples were analyzed and presented as the mean
Huan Wang (109286), Hong Chen (108084), Qian Li (114642)   +2 more
core   +1 more source

Bone mass is inversely proportional to Dkk1 levels in mice [PDF]

Bone, 2007
The Wnt/beta-catenin signaling pathway has emerged as a key regulator in bone development and bone homeostasis. Loss-of-function mutations in the Wnt co-receptor LRP5 result in osteoporosis and "activating" mutations in LRP5 result in high bone mass.
Bryan T, MacDonald, Danese M, Joiner, Sivan M, Oyserman, Parul, Sharma, Steven A, Goldstein, Xi, He, Peter V, Hauschka   +6 more
openaire   +2 more sources

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition [PDF]

, 2018
The WNT pathway has become an attractive target for skeletal therapies. High-bone-mass phenotypes in patients with loss-of-function mutations in the LRP5/6 inhibitor Sost (sclerosteosis), or in its downstream enhancer region (van Buchem disease ...
Ross, Ryan D., Witcher, Phillip C, Horan, Daniel J, Witcher, Phillip C., Miner, Sara E., Kyung Shin Kang, Gabriela G. Loots, Lim, Kyung-Eun, Ryan D. Ross, Alexander G. Robling, Bullock, Whitney A., Kang, Kyung Shin, Kyung-Eun Lim, Loots, Gabriela G, Ross, Ryan D, Adaniya, Alison L., Phillip C. Witcher, Alison L. Adaniya, Horan, Daniel J., Daniel J. Horan, Bullock, Whitney A, Whitney A. Bullock, Robling, Alexander G., Adaniya, Alison L, Loots, Gabriela G., Miner, Sara E, Sara E. Miner, Robling, Alexander G   +27 more
core   +1 more source