Results 41 to 50 of about 18,876 (219)

Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line. [PDF]

PLoS ONE, 2012
Genistein (GEN) is a plant-derived isoflavone and can block uncontrolled cell growth in colon cancer by inhibiting the WNT signaling pathway. This study aimed to test the hypothesis that the enhanced gene expression of the WNT signaling pathway ...
Huan Wang, Qian Li, Hong Chen
doaj   +1 more source

Identification of an immunogenic DKK1 long peptide for immunotherapy of human multiple myeloma

Haematologica, 2020
Dickkopf-1 (DKK1), broadly expressed by tumor cells from human multiple myeloma (MM) and other cancers but absent from most normal tissues, may be an ideal target for immunotherapy. Our previous studies have shown that DKK1 (peptide)-specific cytotoxic T
Rong Li, Chengyun Zheng, Qiang Wang, Enguang Bi, Maojie Yang, Jian Hou, Weijun Fu, Qing Yi, Jianfei Qian   +8 more
doaj   +1 more source

Dkk1: A key molecule in joint remodelling and fibrosis [PDF]

Mediterranean Journal of Rheumatology, 2017
Dickkopf-1 (Dkk-1) is a Wnt signaling pathway inhibitor that has been shown to play an important role in joint remodeling, in experimental models of arthritis and in humans. Recent data suggest that this molecule is involved in the fibrotic process as well.This review summarizes all the available data regarding the role of Dkk-1 in joint remodeling and
Klavdianou, Kalliopi, Liossis, Stamatis-Nick, Daoussis, Dimitrios   +2 more
openaire   +2 more sources

Dkk1 inhibits malignant transformation induced by Bmi1 via the β‐catenin signaling axis in WB‐F344 oval cells

FEBS Open Bio, 2021
Dickkopf‐1 (Dkk1) is an inhibitor of Wnt signaling involved in cancer cell proliferation, apoptosis, and migration and angiogenesis. It was previously reported that B cell‐specific Moloney mouse leukemia virus integration site 1 (Bmi1) activates the Wnt ...
Jinjun Ye, Le Xin, Jidong Liu, Tao Tang, Xing Bao, Yukuang Yan   +5 more
doaj   +1 more source

Estudios funcionales de variantes de DKK1 presentes en la población general

, 2018
Objetivo: En las últimas décadas se han identificado genes asociados a la masa ósea y al riesgo de fractura osteoporótica, varios de los cuales pertenecen a la vía de Wnt.
Civit S, Roca-Ayats N, Mellibovsky L, Balcells S, Díez-Pérez A, Martínez-Gil N, Vilardell M, Urreizti R, Grinberg D, García-Giralt N, Nogués X   +10 more
core   +1 more source

Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss

iScience, 2021
Summary: The Wnt inhibitor Dickkopf-1 (DKK1) is a negative regulator of bone formation and bone mass and is dysregulated in various bone diseases. How DKK1 contributes to postmenopausal osteoporosis, however, remains poorly understood. Here, we show that
Juliane Lehmann, Sylvia Thiele, Ulrike Baschant, Tilman D. Rachner, Christof Niehrs, Lorenz C. Hofbauer, Martina Rauner   +6 more
doaj   +1 more source

Regulation of DKK1 by CT16.

, 2012
(A) Verification of differential DKK1 mRNA expression in (WM-266-4 cells transfected with control cDNA or CT16 cDNA. by qRT-PCR. (B) Differential DKK1 mRNA expression was also repeatable in A2058 cells treated with indicated siRNAs for 48 h.
Hannu Larjava (133088), Laura Laato (133068), Pekka Rappu (133059), Markku Kallajoki (114542), Eveliina Pakula (133062), Jyrki Heino (133094), Aleksi Heino (133065), Seppo Pyrhönen (133078), Camilla Nylund (133056), Laura L. Elo (61005), Pia Vihinen (133074), Gethin R. Owen (133083)   +11 more
core   +1 more source

Differential binding of Lef1 and Msx1/2 transcription factors to Dkk1 CNEs correlates with reporter gene expression in vivo. [PDF]

PLoS ONE, 2014
Besides the active Wnt signalling itself, the extracellular inhibition by Dkk1 is important for various embryonic developmental processes, such as optic vesicle differentiation and facial outgrowth.
Oliver Lieven, Julia Dronka, Stephan Burmühl, Ulrich Rüther   +3 more
doaj   +1 more source

Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men [PDF]

, 2013
Objectives: Wnt signaling pathway may be crucial in the pathogenesis of disuse-induced bone loss. Sclerostin and DKK1, antagonists of the Wnt signaling pathway, were assessed during immobilization by bed rest in young, healthy people.
Heer, M., Rittweger, Jörn, Boehme, Gisela, Frings-Meuthen, Petra, Liphardt, Anna-Maria   +4 more
core  

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source