Results 51 to 60 of about 18,876 (219)

Thrombocyte-derived Dickkopf1 promotes macrophage polarization in the Bleomycin-induced lung injury model

Frontiers in Immunology, 2023
Immune responses are crucial to maintaining tissue homeostasis upon tissue injury. Upon various types of challenges, macrophages play a central role in regulating inflammation and tissue repair processes.
Eun-Ah Sung, Eun-Ah Sung, Min Hee Park, Min Hee Park, SuJeong Song, SuJeong Song, Hasan Alanya, Octavian Henegariu, Jinze Liu, E Zeynep Erson-Omay, Patricia J. Sime, Wook-Jin Chae, Wook-Jin Chae, Wook-Jin Chae   +13 more
doaj   +1 more source

MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression. [PDF]

, 2017
Dickkopf-1 (DKK1) is a powerful antagonist of canonical WNT signaling pathway, and is regarded as a biomarker for osteoporosis. Its expression is highly correlated with bone mass and osteoblasts maturation.
Jianlin Lu, Jiantao Lin, Guanhai Wang, Xiaolin Tang   +3 more
core   +1 more source

Vergleich der maternalen Serumspiegel von DKK1 und die Expression von DKK1 und beta-Catenin in der Plazenta bei präeklamptischen und normalen Schwangerschaften [PDF]

, 2021
Titel: Vergleich der maternalen Serumspiegel von DKK1 und die Expression von DKK1 und β-Catenin in der Plazenta bei präeklamptischen und normalen Schwangerschaften Theoretischer Hintergrund: Präeklampsie zählt zur Gruppe der hypertensiven ...
Fackiner, Lena
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Expression of DKK1 in NSCLC tissues.

, 2013
(A) Expression by immunohistochemical staining. DKK1 strong positive expression in lung cancer showing staining mainly in the cytoplasm of tumor Cells (magnification 100×). Representative DKK1 weak positive lung cancer with pale yellow particles in tumor
Shujun Li (176557), Baoen Shan (442100), Airong Cui (504836), Xuebo Qin (504835), Sen Wei (103178), Xiaolu Wang (504838), Xin Guo (123593), Yuzheng He (504837)   +7 more
core   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer

Nature Communications
Mechanisms related to tumor evasion from NK cell-mediated immune surveillance remain enigmatic. Dickkopf-1 (DKK1) is a Wnt/β-catenin inhibitor, whose levels correlate with breast cancer progression.
Seunghyun Lee, Biancamaria Ricci, Jennifer Tran, Emily Eul, Jiayu Ye, Qihao Ren, David Clever, Julia Wang, Pamela Wong, Michael S. Haas, Sheila A. Stewart, Cynthia X. Ma, Todd A. Fehniger, Roberta Faccio   +13 more
doaj   +1 more source

Expression and functional analysis of Dkk1 during early gonadal development [PDF]

, 2011
WNT signalling plays a central role in mammalian sex determination by promoting ovarian development and repressing aspects of testis development in the early gonad.
P. Koopman, Bowles, J., C.-W. Feng, M.H. Little, Jackson, A., H.S. Chiu, A. Jackson, Chiu, H. S., J. Bowles, Feng, C. -W., Tam, P. P. L., P.P.L. Tam, Little, M. H., Combes, A. N., A.N. Combes, Khoo, P. L., Koopman, P., P.-L. Khoo   +17 more
core   +1 more source

Clinical Significance of a Cell‐Of‐Origin‐Based Classification in Pancreatic Ductal Adenocarcinoma

Cancer Science, EarlyView.
Schematic overview of a cell‐of‐origin‐based classification of pancreatic ductal adenocarcinoma (PDAC), highlighting distinct biological features and therapeutic implications of Acinar‐ and Ductal‐subtypes. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited therapeutic options and poor clinical ...
Tatsuya Kikuchi, Soichiro Ako, Hironari Kato, Hideaki Kinugasa, Masaki Uchida, Takashi Oda, Ryosuke Hirai, Akihiro Matsumi, Kazuya Miyamoto, Hiroyuki Terasawa, Yuki Fujii, Daisuke Uchida, Kazuyuki Matsumoto, Koichiro Tsutsumi, Shigeru Horiguchi, Kazuya Yasui, Tomokazu Fuji, Kosei Takagi, Hirokazu Kato, Tomoyuki Honda, Fumio Otsuka, Motoyuki Otsuka   +21 more
wiley   +1 more source

Effects of DKK1 overexpression in 95C cell.

, 2013
(A) RT-PCR and Western blot analysis of the DKK1 expression. DKK1 level in 95C cell transfected with pCMV-Tag-2b-DKK1 is significantly higher than that in pCMV-Tag-2b and blank control group. (B) The wounded and healing 95C cells.
Shujun Li (176557), Baoen Shan (442100), Airong Cui (504836), Xuebo Qin (504835), Sen Wei (103178), Xiaolu Wang (504838), Xin Guo (123593), Yuzheng He (504837)   +7 more
core   +1 more source