Results 31 to 40 of about 18,876 (219)
Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of Dickkopf-1 (DKK1)
Frontiers in Genetics, 2021 WNT signaling pathway inhibitor Dickkopf-1 (DKK1) is related to cancer progression; however, its diagnostic and prognostic potential have not been investigated in a pan-cancer perspective.
Shuang Gao +4 more
doaj +1 more source
Expression and Significance of Serum DKK1 in Gastric Cancer Patients
Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the expression and significance of serum DKK1 in patients with gastric cancer. Methods We selected 170 gastric cancer patients (gastric cancer group) and 170 subjects with non-gastric cancer during the same period (control group ...
ZHANG Rui +7 more
doaj +1 more source
Scientific Reports, 2021 Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes.
Charles Caldwell +12 more
doaj +1 more source
Cancer Cell International, 2019 Background DKK1 has been reported to act as a tumor suppressor in breast cancer. However, the mechanism of DKK1 inhibits breast cancer migration and invasion was still unclear.
Jie Niu +9 more
doaj +1 more source
Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype. [PDF]
PLoS ONE, 2012 BACKGROUND AND AIM: We investigated the prognostic importance of dickkopf-1(DKK1) and beta-catenin expression in triple negative breast cancers. METHODS: The expression of DKK1 and beta-catenin was evaluated in breast cell lines using RT-PCR and western ...
Wen-Huan Xu +4 more
doaj +1 more source
Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage-Myofibroblast Transition. [PDF]
Adv Sci (Weinh)Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophageâmyofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhang ZH +10 more
europepmc +2 more sources
Roles of Wnt3a and Dkk1 in experimental periodontitis
Journal of Dental Sciences, 2017 Periodontitis is an inflammatory, destructive disease caused by periodontal bacteria, and its molecular mechanism remains unclear. The aims of this study are to evaluate the expressions of Wnt3a and Dkk1 in experimental periodontitis (EP) and preliminarily explore their roles in periodontal diseases.A total of 64 six-week-old male Sprague-Dawley rats ...
Jianqi Liu +5 more
openaire +3 more sources
Zebrafish Dkk1 Functions in Forebrain Specification and Axial Mesendoderm Formation [PDF]
, 2000 We identified a zebrafish homologue of Dickkopf-1 (Dkk1), which was previously identified in Xenopus as a Wnt inhibitor with potent head-inducing activity.
Itoh, Motoyuki +7 more
core +1 more source
Hepatic DKK1-driven steatosis is CD36 dependent
Life Science Alliance, 2022 Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide; about 25% of NAFLD silently progress into steatohepatitis, in which some of them may develop into fibrosis, cirrhosis and liver failure. However, few drugs are available for NAFLD, partly because of an incomplete understanding of its pathogenic mechanisms. Here, using in vivo and in vitro
Zhen Yang +17 more
openaire +2 more sources
Chinese Journal of Lung Cancer, 2023 Background and objective Lung cancer is the most common malignant tumor in China, lung adenocarcinoma (LUAD) is the main type of lung cancer, which is a serious threat to people's life and health.
Ruijiao LU +4 more
doaj +1 more source