Results 21 to 30 of about 18,876 (219)

DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01 [PDF]

, 2022
Background and aims: Dickkopf-1 (DKK1) is associated with poor prognosis in intrahepatic cholangiocarcinoma (iCCA), but the mechanisms behind this are unclear.
Soong, Daniel; id_orcid, Newman, Walter, Kamila I. Musialik, David H. Wilson, Luke Boulter, Jarman, Edward, Ng, Minn-E, Konstantinos Gournopanos, Daniel Y. H. Soong, Gournopanos, Konstantinos, Kagey, Michael H., Scott H. Waddell, Panagiota Tsokkou, Stephanie MacMaster, Tsokkou, Panagiota, Horcas Lopez, Marta, Jeffrey W. Pollard, Marta Horcas‐Lopez, Pollard, Jeffery W, Edward J. Jarman, Michael H. Kagey, Wilson, David, Minn‐E Ng, MacMaster, Stephanie, Waddell, Scott, I. Musialik, Kamila, Cambridge, William, William A. Cambridge, Walter Newman, Boulter, Luke   +29 more
core   +1 more source

Dickkopf-1: A Promising Target for Cancer Immunotherapy

Frontiers in Immunology, 2021
Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated with a poor prognosis.
Hang Yin Chu, Hang Yin Chu, Zihao Chen, Zihao Chen, Luyao Wang, Luyao Wang, Zong-Kang Zhang, Zong-Kang Zhang, Xinhuan Tan, Shuangshuang Liu, Bao-Ting Zhang, Bao-Ting Zhang, Aiping Lu, Aiping Lu, Yuanyuan Yu, Yuanyuan Yu, Ge Zhang, Ge Zhang   +17 more
doaj   +1 more source

Presence of KREMEN receptors for DKK1 in the preimplantation bovine embryo

Reproduction and Fertility, 2023
The WNT inhibitory protein DKK1 has been shown to regulate the development of the preimplantation embryo to the blastocyst stage. In cattle, DKK1 increases the number of trophectoderm cells that are the precursor of the placenta. DKK1 can affect cells by
Thiago Fernandes Amaral, Yao Xiao, Surawich Jeensuk, Tatiane Silva Maia, Camila J Cuellar, Chloe A Gingerich, Tracy L Scheffler, Peter J Hansen   +7 more
doaj   +1 more source

DKK1 as a novel target for myeloma immunotherapy [PDF]

OncoImmunology, 2012
Novel, potent tumor-associated antigens are needed to improve the efficacy of immunotherapy for myeloma. We demonstrated that active vaccination using the DKK1-DNA vaccine in the myeloma mouse model protected mice from developing myeloma and effectively treated established myeloma.
Qian, Jianfei, Yi, Qing
openaire   +2 more sources

Activation and Inhibition of The Wnt3A Signaling Pathway in Buffalo (Bubalus bubalis) Embryonic Stem Cells: Effects of WNT3A, Bio and Dkk1 [PDF]

International Journal of Fertility and Sterility, 2015
Background This research studies the effects of activation and inhibition of Wnt3A signaling pathway in buffalo (Bubalus bubalis) embryonic stem (ES) cell-like cells.
Mohammad Zandi, Syed Mohamad Shah, Musharifa Muzaffar, Manoj Kumar Singh, Prabhat Palta, Suresh Kumar Singla, Radhey Sham Manik, Manmohan Singh Chauhan   +7 more
doaj   +1 more source

The role of Dkk1 in bone mass regulation: Correlating serum Dkk1 expression with bone mineral density [PDF]

Journal of Orthopaedic Research, 2010
AbstractThe Wnt/β‐catenin pathway is a major signaling cascade in bone biology, playing a key role in regulating bone development and remodeling, with aberrations in signaling resulting in disturbances in bone mass. The objectives of our study were to correlate serum Dkk1 expression with bone mineral density (BMD) and assess the potential role of Dkk1 ...
Joseph S, Butler, David W, Murray, Conor J, Hurson, Julie, O'Brien, Peter P, Doran, John M, O'Byrne   +5 more
openaire   +2 more sources

Table1_Drug Discovery of DKK1 Inhibitors.DOCX

, 2022
Dickkopf-1 (DKK1) is a well-characterized Wnt inhibitor and component of the Wnt/β-catenin signaling pathway, whose dysregulation is associated with multiple abnormal pathologies including osteoporosis, Alzheimer’s disease, diabetes, and various cancers.
Zongkang Zhang (12215669), Shanshan Yao (598841), Hang Yin Chu (9576275), Sifan Yu (4848142), Ge Zhang (112487), Yuanyuan Yu (1784494), Bao-Ting Zhang (335503), Hewen Jiang (12215666)   +7 more
core   +1 more source

Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma. [PDF]

PLoS ONE, 2012
The Wnt/β-catenin pathway plays a crucial role in the pathogenesis of various human cancers. In multiple myeloma (MM), aberrant auto-and/or paracrine activation of canonical Wnt signaling promotes proliferation and dissemination, while overexpression of ...
Kinga A Kocemba, Richard W J Groen, Harmen van Andel, Marie José Kersten, Karène Mahtouk, Marcel Spaargaren, Steven T Pals   +6 more
doaj   +1 more source

Prognostic value of Dickkopf-1 and ß-catenin expression in advanced gastric cancer

BMC Cancer, 2018
Background Dickkopf-1 (DKK1) is a Wnt/ß-catenin pathway antagonist related to gastric cancer (GC) carcinogenesis. However, the prognostic role of combined DKK1 and ß-catenin expression in advanced GC (AGC) is not clear.
Soon Auck Hong, Su Hyun Yoo, Han Hong Lee, Der Sheng Sun, Hye Sung Won, Okran Kim, Yoon Ho Ko   +6 more
doaj   +1 more source

Sclerostin and DKK1 in postmenopausal osteoporosis treated with denosumab [PDF]

Journal of Bone and Mineral Research, 2012
Abstract The bone mass benefits of antiresorbers in postmenopausal osteoporosis are limited by the rapid coupling of decreasing bone resorption with bone formation. Wnt signaling is involved in this coupling process during treatment with bisphosphonates, whereas its role during treatment with the anti-receptor activator of NF-κB ...
GATTI, Davide, VIAPIANA, Ombretta, FRACASSI, Elena, IDOLAZZI, Luca, Dartizio C, Povino MR, ADAMI, Silvano, ROSSINI, Maurizio   +7 more
openaire   +3 more sources