Results 11 to 20 of about 18,876 (219)
Distinct roles of DKK1 and DKK2 in tumor angiogenesis [PDF]
Angiogenesis, 2013 Tumor angiogenesis is essential for tumor invasive growth and metastasis, and generates abnormal vascular structures unlike developmental neovessel formation. To reduce tumor vascular abnormalities such as leakage and perivascular cell coverage deficiency that limit cancer therapy effectiveness, novel therapeutic approaches focus on vessel ...
Park, Hongryeol +8 more
openaire +3 more sources
The Dkk1 dose is critical for eye development
Developmental Biology, 2011 During mammalian ocular development, several signaling pathways control the spatiotemporal highly defined realization of the three-dimensional eye architecture. Given the complexity of these inductive signals, the developing eye is a sensitive organ for several diseases. In this study, we investigated a Dkk1+/- haploinsufficiency during eye development,
Lieven, Oliver, Rüther, Ulrich
core +4 more sources
The regulation of Dkk1 expression during embryonic development [PDF]
Developmental Biology, 2010 During embryogenesis, the Dkk1 mediated Wnt inhibition controls the spatiotemporal dynamics of cell fate determination, cell differentiation and cell death. Furthermore, the Dkk1 dose is critical for the normal Wnt homeostasis, as alteration of the Dkk1 activity is associated with various diseases.
Lieven, Oliver +2 more
openaire +3 more sources
Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis.
PLoS ONE, 2011 Dickkopf1 (Dkk1) is a Wnt/β-catenin inhibitor that participates in many processes during embryonic development. One of its roles during embryogenesis is to induce head formation, since Dkk1-null mice lack head structures anterior to midbrain.
Diogo Ribeiro +7 more
doaj +3 more sources
Journal of Translational MedicineIntroduction Intrauterine adhesions (IUA) manifest as endometrial fibrosis, often causing infertility or recurrent miscarriage; however, their pathogenesis remains unclear.
Zhanqin Zhang, Jianguo Hu
doaj +2 more sources
HBx and SP1 upregulate DKK1 expression. [PDF]
Acta Biochimica Polonica, 1970 Numerous evidences suggested that the hepatitis B virus (HBV) was recognized as an important factor in the development of hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) recently was reported to be involved in the progress of HCC. HBV may regulate DKK1 expression in hematoma carcinogenesis.
Hong, Peng +6 more
openaire +4 more sources
Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation. [PDF]
PLoS ONE, 2010 BackgroundThe low density lipoprotein receptor-related protein-6 (LRP6) is an essential co-receptor for canonical Wnt signaling. Dickkopf 1 (Dkk1), a major secreted Wnt signaling antagonist, binds to LRP6 with high affinity and prevents the Frizzled-Wnt ...
Yonghe Li +5 more
doaj +2 more sources
DKK1 as a chemoresistant protein modulates oxaliplatin responses in colorectal cancer
OncogenesisOxaliplatin is effective against colorectal cancer (CRC), but resistance hampers treatment. We found upregulated Dickkopf-1 (DKK1, a secreted protein) in oxaliplatin-resistant (OR) CRC cell lines and DKK1 levels increased by more than 2-fold in ...
Chi-Che Hsieh +6 more
doaj +2 more sources
DKK1 promotes migration and invasion of non–small cell lung cancer via β-catenin signaling pathway
Tumor Biology, 2017 Disregulation of dickkopf-related protein 1 (DKK1) has been reported in a variety of human cancers. However, how DKK1 functions in Non-small cell lung cancer has not been revealed.
Jing Zhang +6 more
doaj +2 more sources
Cancer Management and Research, 2018 Haihe Gao,1 Lisha Li,2 Mang Xiao,3 Yongwei Guo,4 Yi Shen,5,6 Lixin Cheng,5 Ming Tang5 1Department of Otolaryngology Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China; 2Department of Nursing ...
Gao H +6 more
doaj +1 more source