Results 1 to 10 of about 18,876 (219)

DKK1 Induced by 1,25D3 Is Required for the Mineralization of Osteoblasts [PDF]

Cells, 2020
1α,25-dihydroxyvitamin D3 (1,25D3), the most popular drug for osteoporosis treatment, drives osteoblast differentiation and bone mineralization. Wnt/β-catenin signaling is involved in commitment and differentiation of osteoblasts, but the role ...
Jae-Hyuk Yang, Joong-Soo Han, So Young Lee   +2 more
exaly   +6 more sources

Drug Discovery of DKK1 Inhibitors

Frontiers in Pharmacology, 2022
Dickkopf-1 (DKK1) is a well-characterized Wnt inhibitor and component of the Wnt/β-catenin signaling pathway, whose dysregulation is associated with multiple abnormal pathologies including osteoporosis, Alzheimer’s disease, diabetes, and various cancers.
Hewen Jiang, Hewen Jiang, Zongkang Zhang, Zongkang Zhang, Yuanyuan Yu, Yuanyuan Yu, Yuanyuan Yu, Hang Yin Chu, Hang Yin Chu, Sifan Yu, Sifan Yu, Sifan Yu, Shanshan Yao, Shanshan Yao, Ge Zhang, Ge Zhang, Ge Zhang, Bao-Ting Zhang, Bao-Ting Zhang   +18 more
doaj   +3 more sources

DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression

Cell Death and Disease
Super-enhancers are a class of DNA cis-regulatory elements that can regulate cell identity, cell fate, stem cell pluripotency, and even tumorigenesis. Increasing evidence shows that epigenetic modifications play an important role in the pathogenesis of ...
Lan Shao, Haoran Yu, Mengyun Wang, Lu Chen, Boshu Ji, Tong Wu, Xiangqi Teng, Mu Su, Xiao Han, Weikai Shi, Xin Hu, Ziwen Wang, Hongjuan He, Guiping Han, Yan Zhang, Qiong Wu   +15 more
doaj   +3 more sources

T cells engineered against Dickkopf-1-A2 complex can be used to treat HLA-A2+ solid and hematologic cancers [PDF]

Nature Communications
Although chimeric antigen receptor (CAR)-T cells are promising effector cells to treat hematologic tumors, developing effective CAR-T cells for solid tumors remains challenging. Dickkopf-1 (DKK1) protein is widely expressed by human hematologic and solid
Yufei Zhang, Wei Xiong, Jianfei Qian, Rui Duan, Qi Guo, Qiang Wang, Wei Wu, Chuanchao Zhang, Yabo Li, Miao Xian, Yong Lu, Nestor F. Esnaola, Jenny C. Chang, Liuling Xiao, Ling Zhong, Qing Yi   +15 more
doaj   +2 more sources

Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the Patients

Cancer Management and Research, 2021
Guohua Zhu,1,2,* Jukun Song,2,3,* Weimin Chen,3,* Dongbo Yuan,2,3 Wei Wang,2 Xiaoyue Chen,3 Hen Liu,2,4 Hao Su,2,4 Jianguo Zhu1– 4 1Guizhou Medical University, Guiyang, Guizhou Province 550002, People’s Republic of China; 2Department of ...
Jianguo Zhu, Song Jukun, Dongbo Yuan
exaly   +2 more sources

Changes in Serum Dickkopf-1, RANK Ligand, Osteoprotegerin, and Bone Mineral Density after Allogeneic Hematopoietic Stem Cell Transplantation Treatment [PDF]

Endocrinology and Metabolism, 2021
Background Dickkopf-1 (DKK1) regulates bone formation by inhibiting canonical Wnt/β-catenin pathway signaling, and indirectly enhances osteoclastic activity by altering the expression ratio of receptor activator of nuclear factor-κB ligand (RANKL ...
Eunhee Jang, Jeonghoon Ha, Ki-Hyun Baek, Moo Il Kang   +3 more
doaj   +1 more source

Dickkopf-1 is oncogenic and involved in invasive growth in non small cell lung cancer. [PDF]

PLoS ONE, 2013
Dickkopf-1 (DKK1) is an inhibitor of the Wnt/β-catenin signaling pathway. However, the role of DKK1 in the progression of non small cell lung cancer (NSCLC) is not fully understood.
Shujun Li, Xuebo Qin, Xin Guo, Airong Cui, Yuzheng He, Sen Wei, Xiaolu Wang, Baoen Shan   +7 more
doaj   +1 more source

Elevated levels of Dickkopf-1 are associated with β-catenin accumulation and poor prognosis in patients with chondrosarcoma. [PDF]

PLoS ONE, 2014
BACKGROUND: Dickkopf-1 (DKK1) is an antagonist of Wnt/β-catenin signaling implicated in tumorigenesis. However, the biological role of DKK1 and β-catenin involved in chondrosarcoma has not been sufficiently investigated.
Changbao Chen, Hua Zhou, Xiaolin Zhang, Xinlong Ma, Zhongjun Liu, Xiaoguang Liu   +5 more
doaj   +1 more source

Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the tumor response to programmed cell death protein 1 (PD-1) blockade in colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite
Yuan Li, Jian Zheng, Zhizhong Pan, Penghui Zhou, Guochen Liu, Wu Jiang, Pei-Rong Ding, Zexian Liu, Qiaoqi Sui, Dingxin Liu, Jinghua Tang, Lingheng Kong, Kai Han, Leen Liao, Qingjian Ou, Binyi Xiao, Yihong Ling, Jiewei Chen, Zhixiang Zuo   +18 more
doaj   +1 more source

Correlation of NNMT and DKK1 Protein Expression With Clinicopathological Characteristics and Prognosis of Breast Cancer

Clinical Medicine Insights: Oncology, 2023
Background: Nicotinamide N-methyltransferase (NNMT) and Dickkopf-1 (DKK1) play an important role in the development of breast cancer, and the purpose of this study was designed to examine the clinical and prognostic significance of NNMT and DKK1 in ...
Tairong Liang, Xiuqian Wu, Lan Wang, Tiantian Song, Peishan Wu, Yongdong Niu, Haihua Huang   +6 more
doaj   +1 more source