Results 111 to 120 of about 18,876 (219)
The Expression and Significance of Dickkopf-1 in Epithelial Ovarian Carcinoma
The International Journal of Biological Markers, 2009 The aim of this study was to investigate the presence and prognostic value of Dickkopf-1 (DKK1) in epithelial ovarian carcinoma. The expression of DKK1 was determined in 56 epithelial ovarian carcinoma tissues, 35 benign ovarian cystadenoma tissues, and ...
Wang Shizhuo +3 more
doaj +1 more source
Sequence conservation of Tcf/Lef1 binding sites at the Dkk1 locus and coexpression of Lef1 and Dkk1.
, 2014 (A) Schematic representation of the mouse Dkk1 locus, indicating Tcf/Lef1(triangles) and Msx1/2 (diamonds) binding sites addressed in this study. The Dkk1 transcriptional start (arrow) and Dkk1 conserved non-coding elements (CNEs; filled boxes) and their
Oliver Lieven (697918) +3 more
core +1 more source
BMC Cancer, 2019 Background It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear. Methods CRC cases after resection of liver
Qiaoqi Sui +13 more
doaj +1 more source
Journal for ImmunoTherapy of CancerBackground Targeted immunotherapy with monoclonal antibodies (mAbs) is an effective and safe method for the treatment of malignancies. Development of mAbs with improved cytotoxicity, targeting new and known tumor-associated antigens, therefore continues ...
Qiang Wang +12 more
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Andrographolide sensitizes glioma to temozolomide by inhibiting DKK1 expression
British Journal of CancerTemozolomide (TMZ) is the first-line chemotherapeutic drug for gliomas treatment. However, the clinical efficacy of TMZ in glioma patients was very limited. Therefore, it is urgently needed to discover a novel approach to increase the sensitivity of glioma cells to TMZ.Western blot, immunohistochemical staining, and qRT-PCR assays were used to explore ...
Zhan-Sheng Zhang +13 more
openaire +3 more sources
DKK1 neutralizing antibody exhibits modest therapeutic effect in osteogenesis imperfecta
Osteogenesis imperfecta (OI) is a group of monogenic skeletal diseases caused by defect of type I collagen. There is no specific treatment strategy and targeted therapy is urgently needed.
Siji Zhou +12 more
core +1 more source
Reduction in DKK1 expression contributes to linc00467-mediated neuroblastoma cell survival.
, 2014 (A) BE(2)-C and Kelly cells were transfected with scrambled control siRNA, linc00467 siRNA-1 or linc00467 siRNA-2 for 48 hours, followed by RNA extraction and RT-PCR analysis of DKK1 gene expression.
Bernard Atmadibrata (524472) +7 more
core +1 more source
Kaplan-Meier curves based on DKK1 and beta-catenin expression.
, 2013 A) B): Kaplan-Meier estimates for relapse-free survival and overall survival based on DKK1 status. C) D): Kaplan-Meier estimates for relapse-free survival and overall survival based on beta-catenin status.
Wen-Huan Xu (321932) +4 more
core +1 more source
Scientific ReportsWnt signaling is critically involved in fracture healing. Existing data predominantly relies on rodent models. Here, we explored local and circulating Dickkopf-1 (DKK1) levels in patients with respect to fracture healing and explore its association to ...
Julia Starlinger +3 more
doaj +1 more source