Results 1 to 10 of about 15,383 (164)

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis [PDF]

BMC Cancer, 2010
Background Dll4/Notch and Ephrin-B2/EphB4 pathways play critical roles in tumor vessel development and maturation. This study evaluates the efficacy of the inhibition of both signaling pathways, alone and in combination, in reducing the growth of an ...
Liu Ren, Silva Lilliana, Badenes Marina, Gigante Joana, Trindade Alexandre, Djokovic Dusan, Li Xiuqing, Gong Ming, Krasnoperov Valery, Gill Parkash S, Duarte Antonio   +10 more
doaj   +3 more sources

Monocyte-derived Langerhans cells express Delta-like 4 induced by peptidoglycan and interleukin-4 mediated suppression [PDF]

Frontiers in Immunology
T cells contribute to immunotherapy and autoimmune pathogenesis and Langerhans cells (LCs) have a substantial ability to activate T cells. In vitro-generated monocyte-derived LCs (Mo-LCs) are useful models to study LC function in autoimmune diseases and ...
Rei Ono, Kohei Maeda, Toshihiro Tanioka, Takeo Isozaki, Takeo Isozaki   +4 more
doaj   +2 more sources

Notch2/3-DLL4 interaction in urothelial cancer cell lines supports a tumorigenic role of Notch signaling pathways in bladder carcinoma. [PDF]

PLoS ONE
IntroductionThe Notch pathway plays an important role in many aspects of cancer biology and acts in a dichotomous way in bladder cancer. The mechanisms behind this behavior are still elusive.
Chuan Zhang, Annett Weimann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz   +4 more
doaj   +2 more sources

Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine [PDF]

PeerJ, 2014
Reports have suggested that the two Notch ligands, Dll1 and Dll4, are indispensable to maintain the homeostasis of the intestinal epithelium. However, within the intestinal epithelium, the precise distribution of the cells that express those ligands at ...
Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe   +11 more
doaj   +2 more sources

Mycobacterium tuberculosis impedes CD40-dependent notch signaling to restrict Th17 polarization during infection

iScience, 2022
Summary: Early Th17 responses are necessary to provide protection against Mycobacterium tuberculosis (Mtb). Mtb impedes Th17 polarization by restricting CD40 co-stimulatory pathway on dendritic cells (DCs).
Ana Beatriz Enriquez, Jonathan Kevin Sia, Hedwin Kitdorlang Dkhar, Shu Ling Goh, Melanie Quezada, Kristina Larrieux Stallings, Jyothi Rengarajan   +6 more
doaj   +1 more source

Probing Notch1-Dll4 signaling in regulating osteogenic differentiation of human mesenchymal stem cells using single cell nanobiosensor

Scientific Reports, 2022
Human mesenchymal stem cells (hMSCs) have great potential in cell-based therapies for tissue engineering and regenerative medicine due to their self-renewal and multipotent properties.
Yuwen Zhao, Rui Yang, Zoe Bousraou, Kiarra Richardson, Shue Wang   +4 more
doaj   +1 more source

Correlation of serum delta-like ligand-4 level with the severity of diabetic retinopathy

BMC Endocrine Disorders, 2021
Background Diabetic retinopathy (DR) is one of the most serious microvascular complications of type 2 diabetes mellitus (T2DM). Delta-like ligand-4 (DLL4) maintains the normal physiological microenvironment of the retina.
Yan Zhu, Jingcheng Hu, Xuan Du, Qionglei Fang, Yingyi Zhou, Ke Chen   +5 more
doaj   +1 more source

AGEs induce high expression of Dll4 via endoplasmic reticulum stress PERK signaling-mediated internal ribosomal entry site mechanism in macrophages

Heliyon, 2023
Background and aim: Advanced glycation end products (AGEs)- exposed macrophages was characterized by Delta-like ligand 4 (Dll4) high expressed and has been shown to participate in diabetes-related atherosclerosis.
Yanpeng Ma, Shixiang Zheng, Xiqiang Wang, Ling Zhu, Junkui Wang, Shuo Pan, Yong Zhang, Zhongwei Liu   +7 more
doaj   +1 more source

Systemic expression of Notch ligand Delta-like 4 during mycobacterial infection alters the T cell immune response

Frontiers in Immunology, 2016
The Notch ligand Delta-like 4 (DLL4) is known to fine-tune the CD4+ T cell cytokine response. DLL4 is expressed on the surface of antigen presenting cells in a MyD88 dependent manner.
Matthew Schaller, Cheryl L Day, Cheryl L Day, Cheryl L Day, Ronald Melvin Allen, Soichiro Kimura, Steven L Kunkel   +6 more
doaj   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
core   +1 more source