Results 101 to 110 of about 15,452 (227)

Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis.

PLoS ONE, 2012
Recent findings regarding Dll4 function in physiological and pathological conditions indicate that this Notch ligand may constitute an important therapeutic target.
Alexandre Trindade, Dusan Djokovic, Joana Gigante, Marina Badenes, Ana-Rita Pedrosa, Ana-Carina Fernandes, Luís Lopes-da-Costa, Valery Krasnoperov, Ren Liu, Parkash S Gill, António Duarte   +10 more
doaj   +1 more source

Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle [PDF]

, 2013
Articles in International JournalsThe transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key ...
A Fischer, a Hess R, a Hess R, Alexandre Trindade, António Duarte, AR Bellvi, B Bielesz, BR Nebel, C Afonso, C Firlit, C Zeng, Daniel Murta, Domingos Henrique, E Assa-Kunik, E Silva, E Silva, EF OAKBERG, EJ Lambie, EJ Ward, Elisabete Silva, F Batista, G Dirami, H Takanaga, H-T Cheng, HB Ariyaratne, I Sörensen, J Boucher, J Kimble, J Lu, J Zavadil, Jean-Marc A. Lobaccaro, K Hasegawa, K Shimizu, KL Hahn, LT Krebs, Luís Lopes-da-Costa, M Lupien, M Morimoto, M Rahmana, M Stahl, M-C Hofmann, Marta Batista, Mruk Wong, EWP Dolores D, R Bultje, R Habert, RM Das, S Artavanis-Tsakonas, S Kimmins, S Mori, SS Saravanamuthu, T Borggrefe, T DeFalco, T Hayashi, T Hayashi, T Kitamoto, TX Garcia, V Von Schönfeldt, X Feng, X Song, Y Clermont, Y Kitadate, Y Niwa, Y Wang, Z Sahin, Z Yuan   +64 more
core   +3 more sources

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Deleted in Malignant Brain Tumors 1 is Present in the Vascular Extracellular Matrix and Promotes Angiogenesis [PDF]

, 2012
Objective— Deleted in malignant brain tumors 1 (DMBT1) belongs to the scavenger receptor cysteine-rich superfamily of proteins and is implicated in innate immunity, cell polarity, and differentiation.
Eble, Johannes A, Fisslthaler, Beate, Fleming, Ingrid, Hu, Jiong, Mollenhauer, Jan, Müller-Decker, Karin, Müller-Enbergs, Helmut, Popp, Rüdiger, Schmidt, Henrik   +8 more
core   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, Volume 6, Issue 3, March 2026.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

ROLE OF THE NOTCH1 GENE IN FORMATION OF AORTIC ANEURYSM

Российский кардиологический журнал, 2018
Aim. To evaluate the impact of genetics in development of thoracic aneurysm in patients with tricuspid valve (TAV) and bicuspid aortic valve (BAV) based on the analysis and search for mutations in NOTCH1.Material and methods.
O. V. Irtyuga, O. A. Freilichman, D. S. Krivonosov, A. B. Malashicheva, S. I. Tarnovskaya, V. Е. Uspenskiy, M. L. Gordeev, O. P. Rotar, A. A. Kostareva, O. M. Moiseeva   +9 more
doaj   +1 more source

MAGP2 Controls Notch via Interactions with RGD Binding Integrins: Identification of a Novel ECM-Integrin-Notch Signaling Axis [PDF]

, 2016
Canonical Notch signaling involves Notch receptor activation via interaction with cell surface bound Notch ligand. Recent findings also indicate that Notch signaling may be modulated by cross-talk with other signaling mechanisms.
Albig, Allan R., Brown, Kasey, Deford, Peter, King, Aric, Newburn, Kristin, Richards, Rae Lee, Westover, Katherine   +6 more
core   +2 more sources

Polyethylenimine Triggers Dll4 Degradation to Regulate Angiogenesis In Vitro

ACS Omega
The Dll4-Notch signaling pathway plays a crucial role in the regulation of angiogenesis and is a promising therapeutic target for diseases associated with abnormal angiogenesis, such as cancer and ophthalmic diseases. Here, we find that polyethylenimine (PEI), a cationic polymer widely used as nucleic acid transfection reagents, can target the Notch ...
Binghua Cheng, Yanyan Li, Ya-Bin Ji, Wenli Shi, Meiqing Li, Jiwei Zheng, Li Ding, Ke Liu, Lijing Fang, Ye Xu, Hongchang Li, Ximing Shao   +11 more
openaire   +3 more sources

An Updated Narrative Review on the Therapeutic Potential of Resveratrol in the Treatment of Cancer

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Cancer is a significant global health challenge, affecting millions of people every year. Overall survival rates have improved over time, but some patients exhibit treatment resistance, prompting ongoing research to find suitable and effective sensitizers.
Mohammad Ashraful Islam, Al Amin, Md. Abdul Aziz, Md. Mahabubur Rahaman, Jakir Hossain, Jakir Ahmed Chowdhury, Mohammad Safiqul Islam   +6 more
wiley   +1 more source

Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable [PDF]

, 2016
__Background:__ Allergic asthma is characterized by a TH2 response induced by dendritic cells (DCs) that present inhaled allergen. Although the mechanisms by which they instruct TH2 differentiation are still poorly understood, expression of the Notch ...
Amsen, D. (Derk), Bruijn, M.J.W. (Marjolein) de, Hendriks, R.W. (Rudi), Kleinjan, A. (Alex), Li, B.W.S. (Bobby), Lukkes, M. (Melanie), Nimwegen, M. (Menno) van, Tindemans, I. (Irma)   +7 more
core   +1 more source