Results 101 to 110 of about 15,361 (230)
PLoS ONE, 2013 BackgroundEndothelial DLL4 plays an important role in controlling of tumor angiogenesis, which is required for tumor invasive growth and metastasis.
Qing Bo Huang +12 more
doaj +1 more source
Deleted in Malignant Brain Tumors 1 is Present in the Vascular Extracellular Matrix and Promotes Angiogenesis [PDF]
, 2012 Objective— Deleted in malignant brain tumors 1 (DMBT1) belongs to the scavenger receptor cysteine-rich superfamily of proteins and is implicated in innate immunity, cell polarity, and differentiation.
Eble, Johannes A +8 more
core +1 more source
International Journal of Applied Linguistics, EarlyView.ABSTRACT Given the importance of the linguistic landscape in language learning, the digital linguistic landscape (DLL) has emerged as an important multimodal input resource. However, few studies have been conducted to explore the antecedent and predictive effect of the DDL on L2 writing. To address this gap, the study attempted to conceptualize the DLL
Zi Yang, Lawrence Jun Zhang
wiley +1 more source
PLoS ONE, 2012 Recent findings regarding Dll4 function in physiological and pathological conditions indicate that this Notch ligand may constitute an important therapeutic target.
Alexandre Trindade +10 more
doaj +1 more source
MAGP2 Controls Notch via Interactions with RGD Binding Integrins: Identification of a Novel ECM-Integrin-Notch Signaling Axis [PDF]
, 2016 Canonical Notch signaling involves Notch receptor activation via interaction with cell surface bound Notch ligand. Recent findings also indicate that Notch signaling may be modulated by cross-talk with other signaling mechanisms.
Albig, Allan R. +6 more
core +2 more sources
Immunology, EarlyView.RNA‐seq of lungs and livers from Mycobacterium tuberculosis‐infected mice with distinct disease outcomes revealed organ‐specific responses driven by differences in immune activity and bacterial burden. Meta‐analysis identified orthologous genes shared with human latent TB and mouse liver, with Creb3l1, Myo7b, Cyyr1 and Cbs differentially expressed and ...
Felipe T. Lima +9 more
wiley +1 more source
Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade
eLife, 2019 Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus (SV)
Stanislao Igor Travisano +9 more
doaj +1 more source
Dynamic Ligand Discrimination in the Notch Signaling Pathway [PDF]
, 2018 The Notch signaling pathway comprises multiple ligands that are used in distinct biological contexts. In principle, different ligands could activate distinct target programs in signal-receiving cells, but it is unclear how such ligand discrimination ...
Bronner, Marianne E. +5 more
core +1 more source
Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable [PDF]
, 2016 __Background:__ Allergic asthma is characterized by a TH2 response induced by dendritic cells (DCs) that present inhaled allergen. Although the mechanisms by which they instruct TH2 differentiation are still poorly understood, expression of the Notch ...
Amsen, D. (Derk) +7 more
core +1 more source
Journal of Periodontal Research, EarlyView.The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag +6 more
wiley +1 more source