Results 91 to 100 of about 10,317 (177)

Preliminary Research of Main Components of Dll4/ Notch-VEGF Signaling Pathway Under High-Glucose Stimulation in vitro

Diabetes, Metabolic Syndrome and Obesity, 2022
Na Gao,1,* Linghui Xiao,1,* Zheng Tao,2 Yanlin Zheng,1 Wanjie Wang,1 Hui Huang1 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of China; 2Eye College, Chengdu University of ...
Gao N, Xiao L, Tao Z, Zheng Y, Wang W, Huang H   +5 more
doaj  

Correlation between pre-operative VE-cadherin and DLL4 and the maturation after primary arteriovenous fistula in uremic patients [PDF]

PeerJ
Aims Uremic patients require dialysis to replace the declined kidney function, and arteriovenous fistula (AVF) is a commonly used dialysis access route. Our study aimed to explore vascular endothelial cells cadherin (VE-cadherin) and Delta-like ligand 4 (
Huanhuan Yin, Yifan Tang, Yanping Wang, Yousuf Abdulkarim Waheed, Disheng Wang, Dong Sun   +5 more
doaj   +2 more sources

Notch2/3-DLL4 interaction in urothelial cancer cell lines supports a tumorigenic role of Notch signaling pathways in bladder carcinoma.

PLoS ONE
IntroductionThe Notch pathway plays an important role in many aspects of cancer biology and acts in a dichotomous way in bladder cancer. The mechanisms behind this behavior are still elusive.
Chuan Zhang, Annett Weimann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz   +4 more
doaj   +1 more source

Concurrent Treatment with Anti-DLL4 Enhances Antitumor and Proapoptotic Efficacy of a γ-Secretase Inhibitor in Gastric Cancer

Translational Oncology, 2018
The Notch signaling pathway has been identified as a therapeutic target for cancers. γ-Secretase inhibitors (GSIs) have been progressively recognized as potential anticancer drugs.
Muxing Kang, Yaoyi Zhang, Xiaoli Jin, Guofeng Chen, Yi Huang, Dan Wu, Guogang Li, Jianzhen Shan, Pintong Huang, Jian Chen   +9 more
doaj   +1 more source

Mechanisms of DLL4/Notch and BMP9 Mediated Endothelial Cell Quiescence

, 2015
Endothelial cell quiescence and homeostasis is required for maintaining vascular function, but various pathological states and therapeutic interventions disrupt this homeostasis and exacerbate vascular dysfunction and disease. Notch and BMP signaling are
Rostama, Bahman
core  

Elucidating the input of notch ligand delta-like 4 (dll4) in zebrafish blood stem cell ontogeny

, 2014
Multipotent haematopoietic stem cells (HSCs) supply the organism with mature blood cells of all lineages throughout adult life. These cells first originate in the dorsal aorta (DA) of the vertebrate embryo, and a multitude of signalling pathways ...
Patient, Roger, Schneider, Janina Anne, Schneider, Janina   +2 more
core   +1 more source

Endothelial-specific effects of anti-Dll4 treatment.

, 2012
(A) Immunofluorescence for CD105 and c-kit (Zeiss AxioImager.Z1). Arrowhead, CD105+c-kit− blood vessel; arrow, CD105+c-kit+ blood vessel. Bar = 20 µm.
Diana Martins (109166), António Duarte (109168), Francisco Caiado (109164), Sergio Dias (109172), Ana Bastos-Carvalho (109165), Hideo Yagita (109170), Leonor Remédio (109162), Tânia Carvalho (109163)   +7 more
core   +1 more source

Polyethylenimine Triggers Dll4 Degradation to Regulate Angiogenesis In Vitro

The Dll4-Notch signaling pathway plays a crucial role in the regulation of angiogenesis and is a promising therapeutic target for diseases associated with abnormal angiogenesis, such as cancer and ophthalmic diseases. Here, we find that polyethylenimine (
Meiqing Li (7306043), Ye Xu (29869), Lijing Fang (1499899), Yanyan Li (345271), Ya-Bin Ji (17922915), Li Ding (16240), Ximing Shao (8190192), Wenli Shi (665036), Ke Liu (121889), Binghua Cheng (14164816), Hongchang Li (848914), Jiwei Zheng (14164807)   +11 more
core   +1 more source

miR-30a and DLL4 played opposite roles in the proliferation and migration of HUVEC-C cells.

, 2013
(A) DLL4-transfected HUVEC-C cells gained more proliferation capacity than control cells detected by MTS assay (left panel), while miR-30a suppressed HUVEC-C cell proliferation relative to control cells (middle panel).
Bao Jun Wang (427671), Tao Ping Shi (427670), Yu Gao (69071), Xin Ma (37268), Dong Ni (172495), Tao Zheng (146941), Hong Zhao Li (427672), Yang Fan (220863), Shang Wen Liu (427669), Qing Ai (172475), Qing Bo Huang (427668), Yu Zhang (12946), Xu Zhang (49484)   +12 more
core   +1 more source

The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis.

, 2012
Delta-like 4 (DLL4), a membrane-bound ligand belonging to the Notch signaling family, plays a fundamental role in vascular development and angiogenesis. We identified a conserved microRNA family, miR-30, which targets DLL4.
Georgopoulou, D, Boshoff, Chris, Boshoff, C, Lagos, Dimitris, Bridge, Gemma, Monteiro, Rui; id_orcid, Emuss, Victoria, Henderson, S, Monteiro, Rui, Patient, R, Henderson, Stephen, Lagos, D, Georgopoulou, Dimitra, Patient, Roger, Monteiro, R, Bridge, G, Emuss, V   +16 more
core   +1 more source