Results 101 to 110 of about 10,317 (177)

Endothelial differentiation and remodelling defects in Dll4 mutant EBs.

, 2012
(A) Flow cytometry analysis of Tie2+Flk1+CD41− cells in WT, Dll4+/− and Dll4−/− EBs from day 3 to day 6 of differentiation. (B) Bright field image of a WT EB, at day 25 of differentiation, showing sprouts in methylcellulose medium.
Isabel Alcobia (171113), Catarina C. Carvalho (171135), António Duarte (109168), Leonor Parreira (171141), Pedro Saavedra (171130), António Cidadão (171139), Hélia Neves (171118), Andreia C. Gomes (171124), Ricardo Laranjeiro (171108)   +8 more
core   +1 more source

Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis

Journal of Neuroinflammation
Under neuroinflammatory conditions, astrocytes acquire a reactive phenotype that drives acute inflammatory injury as well as chronic neurodegeneration.
Pierre Mora, Margaux Laisné, Célia Bourguignon, Paul Rouault, Béatrice Jaspard-Vinassa, Marlène Maître, Alain-Pierre Gadeau, Marie-Ange Renault, Sam Horng, Thierry Couffinhal, Candice Chapouly   +10 more
doaj   +1 more source

중추신경계에서 Dll4 및 Sox17의 혈관 안정성 조절

, 2021
학위논문(박사) - 한국과학기술원 : 의과학대학원, 2021.8,[iv, 62 p. :]Part I. Although hypertension is a well-known risk factor of brain diseases associated with blood-brain barrier (BBB) disruption, the location and pathophysiology of hypertension-induced BBB disruption ...
Kim, Soo Hyun
core  

Functional diversity of extracellular matrix components during vessel migration, endothelial sprouting and blood vessel stabilization

, 2009
The formation of mature blood vessels requires recruitment of mural cells (MC) and generation of an extracellular matrix in order to stabilize and support the nascent vessel.
Stenzel, D.
core  

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development

, 2011
The Notch signaling pathway plays a fundamental role during blood vessel development. Notch signaling regulates blood vessel morphogenesis by promoting arterial endothelial differentiation and pro-viding spatial and temporal control over “tip cell ...
Christian W. Siebel, Hao Chen, Gu Zhang, Kyle Niessen, Minhong Yan, John Brady Ridgway, Ganesh Kolumam   +6 more
core   +1 more source

Clinical implications of DLL4 expression in gastric cancer

Background: Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been clarified. Methods: Gastric cancer
石神, 純也, Uchikado, Yasuto, ウエノ, シンイチ, キタ, ヨシアキ, 瀬戸山, 徹郎, 中条, 哲浩, Setoyama, Tetsuro, ニシゾノ, ユカ, ナツゴエ, ショウジ, 喜島, 祐子, Arigami, Takaaki, Kurahara, Hiroshi, 喜多, 芳昭, イシガミ, スミヤ, Nakajo, Akihiro, Kijima, Yuko, キジマ, ユウコ, 奥村, 浩, クラハラ, ヒロシ, Nishizono, Yuka, ナカジョウ, アキヒロ, ウエノソノ, ヨシカズ, Ishigami, Sumiya, オクムラ, ヒロシ, 上野, 真一, Okumura, Hiroki, 藏原, 弘, 内門, 泰斗, 西園, 由香, Ueno, Shinichi, アリガミ, タカアキ, セトヤマ, テツロウ, 有上, 貴明, ウチカド, ヤスト, Kita, Yoshiaki, 上之園, 芳一, Uenosono, Yoshikazu, オオワキ, テツヒロ, 大脇, 哲洋, Owaki, Tetsuhiro, 夏越, 祥次, Natsugoe, Shoji   +41 more
core  

DLL4-targeted CAR-T therapy sensitizes neoadjuvant chemotherapy via eliminating cancer stem cells and reshaping immune microenvironment in HER2+ breast cancer

Journal for ImmunoTherapy of Cancer
Background Neoadjuvant therapy with trastuzumab, pertuzumab and paclitaxel (THP) has significantly improved the prognosis of patients with human epidermal growth factor receptor 2 (HER2)+ breast cancer (BC).
Tianxing Zhou, Yongjie Xie, Yanfang Yang, Ziyun Liu, Jingrui Yan   +4 more
doaj   +1 more source

Dll4/Notch 신호의 중추신경계 혈관장벽 유지기전

학위논문(박사) - 한국과학기술원 : 의과학대학원, 2024.2,[iii, 71 p. :]Dll4/Notch signaling is reported to regulate angiogenesis through tip-stalk cell differentiation and arterial specification in the central nerve system (CNS). Robust expression of Dll4 in endothelial cell
백승은, Baek, Seung Eun
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Notch 신호의 ligand 인 DLL4 가 대사질환 조절에 미치는 기능에 대한 연구

, 2020
Delta-like 4 (DLL4), one of ligands of Notch signaling, which is mostly known to regulate development, morphogenesis, cell differentiation or stem cell maintenance.
김다현
core  

DLL4 conveys Notch-dependent signals achieving selective macrophage differentiation or death

, 2017
International audienceMolecular mechanisms underlying vascular and inflammatory cell network at endothelial and macrophage levels are still unclear. Here we found that microvascular inflammation associates with changes in Notch signaling at endothelium ...
Gérard, N., Hulin, Philippe, Nedellec, Steven, Pabois, Angélique, Laboisse, Christian, Pagie, S., Toquet, Claire, Pattier, Sabine, Charreau, Béatrice   +8 more
core