Results 81 to 90 of about 10,317 (177)

ROLE OF THE NOTCH1 GENE IN FORMATION OF AORTIC ANEURYSM

Российский кардиологический журнал, 2018
Aim. To evaluate the impact of genetics in development of thoracic aneurysm in patients with tricuspid valve (TAV) and bicuspid aortic valve (BAV) based on the analysis and search for mutations in NOTCH1.Material and methods.
O. V. Irtyuga, O. A. Freilichman, D. S. Krivonosov, A. B. Malashicheva, S. I. Tarnovskaya, V. Е. Uspenskiy, M. L. Gordeev, O. P. Rotar, A. A. Kostareva, O. M. Moiseeva   +9 more
doaj   +1 more source

Supplementary information from Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation

, 2016
Supplemental Methods: including HUVEC fibrin gel bead assay, Production of anti-DLL4 F(ab')2, Mouse neonatal retina assay, Xenograft tumor models, Histological analysis of mouse liver, PK assay methods, and Anti-therapeutic antibody assay method.
Sarajane Ross (14881149), Joseph C. Beyer (14999039), Jessica A. Couch (14999036), Jacqueline Tarrant (14999045), John Brady Ridgway (14999051), Maciej Paluch (14999054), Nicholas Lewin-Koh (407648), Jane Ruppel (7912292), Minhong Yan (338717), Sharon Yee (1577428), Priyanka Gupta (638633), Gary Cain (2803033), Gu Zhang (847346), Christina L. Zuch de Zafra (14999042), Philip E. Hass (1593538), Ryan Cook (1958671), Amrita V. Kamath (7572575), Jayme Franklin (14999057), Siao Ping Tsai (1958665), Krishna P. Allamneni (14999048)   +19 more
core   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 780-818, May 2026.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo [PDF]

, 2011
How individual components of the vascular basement membrane influence endothelial cell behaviour remains unclear. Here we show that laminin α4 (Lama4) regulates tip cell numbers and vascular density by inducing endothelial Dll4/Notch signalling in vivo ...
Domogatskaya, A., Ian Rosewell, Collinson, L., Soline Estrach, Amel Mettouchi, Andreas Schertel, Claudio A Franco, Sergey Rodin, Estrach, S., Schertel, A., Stenzel, D., Franco, C.A., Rosewell, I., Karl Tryggvason, Hannah Armer, Mettouchi, A., Tryggvason, K., Sauvaget, D., Armer, H., Lucy Collinson, Lydia Sorokin, Sorokin, L., Holger Gerhardt, Dominique Sauvaget, Rodin, S., Gerhardt, H., Anna Domogatskaya, Denise Stenzel   +27 more
core   +1 more source

Age‐Associated Impairment of Paneth Cells Driven by microRNA‐152 Promotes Intestinal Epithelial Vulnerability to Pathological Stress

Aging Cell, Volume 25, Issue 5, May 2026.
Aging associated miR‐152 dysregulation plays a central role in the loss of Paneth cell homeostasis by inhibiting mitochondrial protein Prohibitin1 (PHB1) expression, which contributes to increased small intestinal vulnerability to pathological stresses. ABSTRACT Advanced age is a well‐known risk factor for severe complications in surgical patients with
Bridgette Warner, Haonan Zhao, Hongxia Chen, Amy VanderStoep, Ana S. G. Cunningham, Dongyoon Yoo, Hee K. Chung, Christine Brantner, Jennifer Coleman, Joungil Choi, Rosemary Kozar, Myriam Gorospe, Jian‐Ying Wang, Lan Xiao   +13 more
wiley   +1 more source

Supplementary Figures 1-5 from Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent on Targeting DLL4-Notch Signaling in Both Tumor and Vasculature Cells

, 2012
PDF file - 139K, Figure S1. DLL4 expression in pancreatic tumor xenografts relative to normal human pancreas. Figure S2. Effect of anti-DLL4 on growth of orthotoptically implanted pancreatic xenograft tumors. Figure S3.
Ann M. Kapoun (8561814), John Lewicki (271668), Xiaomei Song (2379523), Wan-Ching Yen (11520727), Diane M. Simeone (190084), Timothy Hoey (4919833), Austin Gurney (259745), Jingjiang Wu (539653), Edward Kim (49657), Lucia Beviglia (271656), Mark Hynes (539654), V. Pete Yeung (14991083), Marcus M. Fischer (14922470)   +12 more
core   +1 more source

Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis.

PLoS ONE, 2012
Recent findings regarding Dll4 function in physiological and pathological conditions indicate that this Notch ligand may constitute an important therapeutic target.
Alexandre Trindade, Dusan Djokovic, Joana Gigante, Marina Badenes, Ana-Rita Pedrosa, Ana-Carina Fernandes, Luís Lopes-da-Costa, Valery Krasnoperov, Ren Liu, Parkash S Gill, António Duarte   +10 more
doaj   +1 more source

Anti-Dll4 treatment perturbs hematopoiesis following irradiation.

, 2012
(A) Flow cytometric analysis of the percentage of myeloid (CD11b+) cells, T lymphocytes (CD3+ cells), and B lymphocytes (B220+) in the BM and PB, revealing an increase in both myeloid BM and PB content and a decrease in T and B lymphocyte BM content in ...
Diana Martins (109166), António Duarte (109168), Francisco Caiado (109164), Sergio Dias (109172), Ana Bastos-Carvalho (109165), Hideo Yagita (109170), Leonor Remédio (109162), Tânia Carvalho (109163)   +7 more
core   +1 more source

Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade

eLife, 2019
Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus (SV)
Stanislao Igor Travisano, Vera Lucia Oliveira, Belén Prados, Joaquim Grego-Bessa, Rebeca Piñeiro-Sabarís, Vanesa Bou, Manuel J Gómez, Fátima Sánchez-Cabo, Donal MacGrogan, José Luis de la Pompa   +9 more
doaj   +1 more source

Analysis of Flk1 expression and BL-CFC potential of WT and Dll4 mutant EBs.

, 2012
(A) Flow cytometry analysis of Flk1 expression in WT, Dll4+/− and Dll4−/− EBs from day 2 to day 6 of differentiation. (B) Number of blast colonies generated by WT, Dll4+/− and Dll4−/− EB cells from day 2 to day 5 of differentiation.
Isabel Alcobia (171113), Catarina C. Carvalho (171135), António Duarte (109168), Leonor Parreira (171141), Pedro Saavedra (171130), António Cidadão (171139), Hélia Neves (171118), Andreia C. Gomes (171124), Ricardo Laranjeiro (171108)   +8 more
core   +1 more source