Results 71 to 80 of about 10,317 (177)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

miR-124 promotes proliferation and differentiation of neuronal stem cells through inactivating Notch pathway

Cell & Bioscience, 2017
Background Neural stem cells (NSCs) are able to differentiate into neurons and astroglia. miRNAs have been demonstrated to be involved in NSC self-renewal, proliferation and differentiation.
Shujie Jiao, Yaling Liu, Yaobing Yao, Junfang Teng   +3 more
doaj   +1 more source

Involvement of endothelial DLL4 in NOTCH3/Asef-mediated cell migration.

, 2013
(A) Suppression of DLL4 expression by siRNA. Lysates prepared from HUVECs transfected with an siRNA targeting DLL4 or control siRNA were analysed by immunoblot with antibodies against DLL4. Antibodies against α-tubulin were used as a control.
Yoshihiro Kawasaki (482212), Masaya Hiyoshi (482214), Masaya Miyamoto (482213), Tetsu Akiyama (104455), Shiori Furukawa (482211), Joji Kitayama (55603)   +5 more
core   +1 more source

Interleukin‐37 in Cancer Angiogenesis: Mechanisms, Therapeutic Potential, and Future Perspectives

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Interleukin‐37 (IL‐37), a member of the interleukin‐1 family, is recognized as a key anti‐inflammatory cytokine that not only suppresses innate immune responses but also plays a significant role in regulating tumorigenesis, particularly angiogenesis.
Elahe Saberi Teimourian, Mohammad Ali Karimi, Edessa Negera, Ghazaleh Behrouzian Fard, Anas Sattar, Mahdi Hosseini Bafghi, Nirusha Weerasinghe   +6 more
wiley   +1 more source

Hepatitis B Virus HBx Activates Notch Signaling via Delta-Like 4/Notch1 in Hepatocellular Carcinoma. [PDF]

PLoS ONE, 2016
Hepatitis virus B (HBV) infection is one of the major causes of hepatocellular carcinomas (HCC). HBx protein encoded in HBV genome is one of the key viral factors leading to malignant transformation of infected cells.
Pornrat Kongkavitoon, Pisit Tangkijvanich, Nattiya Hirankarn, Tanapat Palaga   +3 more
doaj   +1 more source

Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy. Created in BioRender. Jain, E. (2026) https://BioRender.com/x4f9o8g. ABSTRACT Osteoarthritis (OA) is a highly prevalent, disabling, and painful disease of the joints, characterized by progressive cartilage degeneration, synovial fibrosis, and pain.
Era Jain, Paul Nana Kwame Sagoe
wiley   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Down-Regulated miR-30a in Clear Cell Renal Cell Carcinoma Correlated with Tumor Hematogenous Metastasis by Targeting Angiogenesis-Specific DLL4.

PLoS ONE, 2013
BackgroundEndothelial DLL4 plays an important role in controlling of tumor angiogenesis, which is required for tumor invasive growth and metastasis.
Qing Bo Huang, Xin Ma, Xu Zhang, Shang Wen Liu, Qing Ai, Tao Ping Shi, Yu Zhang, Yu Gao, Yang Fan, Dong Ni, Bao Jun Wang, Hong Zhao Li, Tao Zheng   +12 more
doaj   +1 more source

The role of DLL4-NOTCH signalling in endothelial cell metabolism

, 2014
Tumour tissue is characterised by fluctuating oxygen concentrations, decreased nutrient supply, and acidic pH. Angiogenic signalling pathways that drive a certain metabolic 'configuration' may give endothelial cells a selective advantage in the tumour ...
Harjes, Ulrike
core   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source