Results 61 to 70 of about 10,317 (177)

Delta- like ligand 4- expressing macrophages and human diseases: Insights into pathophysiology and therapeutic opportunities

Heliyon, 2023
Macrophages are key players in the immune response and have been implicated in various human diseases, including atherosclerosis, cancer, and chronic inflammatory disorders.
Ya Yuwen, Xiqiang Wang, Jing Liu, Zhongwei Liu, Haitao Zhu   +4 more
doaj   +1 more source

Wound Healing and Angiogenic Profiling of Dermal Endothelial Cells Isolated From People With Type 2 Diabetes

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Primary human dermal microvascular endothelial cells (HDMVECs) isolated from individuals with type 2 diabetes (T2D) exhibit dysregulated intrinsic properties, including altered morphology, reduced nitric oxide (NO) availability, and loss of endothelial identity.
James Shadiow, Corey E. Mazo, Pallavi Varshney, Jeongjin J. Kim, Alexander Ahn, Sophie H. Chong, Cory A. Lutz, Crystal M. Holmes, Michael E. Munson, Brian M. Schmidt, Sascha N. Goonewardena, Richard D. Minshall, Thomas P. J. Solomon, Andrew T. Ludlow, Jacob M. Haus   +14 more
wiley   +1 more source

DLL4 is a direct target of miR-30a.

, 2013
(A) Putative complementary site of DLL4 mRNA 3′-UTR for the seed region of miR-30a identified by prediction programs. (B) Endothelial HUVEC-C cells were transfected with DLL4 3′-UTR vector and miR-30a vector or negative control vector (pcDNA3.0) for 48 ...
Bao Jun Wang (427671), Tao Ping Shi (427670), Yu Gao (69071), Xin Ma (37268), Dong Ni (172495), Tao Zheng (146941), Hong Zhao Li (427672), Yang Fan (220863), Shang Wen Liu (427669), Qing Ai (172475), Qing Bo Huang (427668), Yu Zhang (12946), Xu Zhang (49484)   +12 more
core   +1 more source

Integrative Single‐Cell RNA Sequencing and Spatial Transcriptomics Uncover Distinct Fibroblast–Macrophage Crosstalk in Human Hip Synovium Between Patients With Femoroacetabular Impingement and Osteoarthritis

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1219-1230, June 2026.
Objective Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell–cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Analysis of Dll4 using immunohistochemistry.

, 2013
The protein expression of Dll4 was up-regulated in missed abortion (A) than that in induced abortion (B).
Yuyan Ma (169643), Beihua Kong (146639), Ping Sun (59933), Shuang Yu (181261), Daoxin Ma (212170), Chunyan Ji (443711), Yan Fang (443710)   +6 more
core   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Dll4 신호체계의 내피세포 안정화 작용

, 2020
학위논문(박사) - 한국과학기술원 : 의과학대학원, 2020.2,[v, 101 p. :]Part I. Dll4 suppresses transcytosis for arterial blood-retina barrier homeostasis The retina with the blood-retina barrier (BRB) maintains low vascular permeability by organizing tight junction (TJ) and ...
Yang, Jee Myung
core  

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation [PDF]

, 2017
Endothelial sprouting and proliferation are tightly coordinated processes mediating the formation of new blood vessels during physiological and pathological angiogenesis.
Ralf H. Adams, Mara E. Pitulescu, Schmidt, Inga, Manuel Ehling, Pitulescu, Mara E, Ehling, Manuel, Adams, Ralf H, Biljes, Daniel, Giaimo, Benedetto Daniele, Ferrante, Francesca, Urs H. Langen, Martin Stehling, Rocha, Susana F, Stehling, Martin, Napoleone Ferrara, Frank Berkenfeld, Ferrara, Napoleone, Tobiah Antoine, Nagasawa, Takashi, Langen, Urs H, Inga Schmidt, Benedetto Daniele Giaimo, Tilman Borggrefe, Susana F. Rocha, Berkenfeld, Frank, Daniel Biljes, Antoine, Tobiah, Francesca Ferrante, Takashi Nagasawa, Borggrefe, Tilman, Hongryeol Park, Park, Hongryeol   +31 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, Volume 16, Issue 5, Page 979-999, May 2026.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Expression of DLL4 and VEGF in Lung Adenocarcinoma and their Relationship with Angiogenesis in Tumor

Chinese Journal of Lung Cancer, 2009
Background and objective Angiogenesis depends on the interaction of a variety of promoting factors and inhibiting factors. Vascular endothelial growth factor (VEGF) and Notch signaling pathway take part in this process.
Xiaoping LI, Qingfu ZHANG, Bin LU, Xueshan QIU, Yang LUO, Weidong ZHANG, Shun XU   +6 more
doaj