Results 111 to 120 of about 15,452 (227)
Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
Vascular Cell, 2011 DLL4 is a ligand for the Notch family of receptors. DLL4 has many important functions in normal development and tissue homeostasis, including roles in the immune system, the gastro-intestinal tract, and in vascular development. Because of the importance of Notch signaling in stem cell biology, DLL4 has been investigated for its role in the maintenance ...
Gurney, Austin, Hoey, Timothy
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Dynamic Ligand Discrimination in the Notch Signaling Pathway [PDF]
, 2018 The Notch signaling pathway comprises multiple ligands that are used in distinct biological contexts. In principle, different ligands could activate distinct target programs in signal-receiving cells, but it is unclear how such ligand discrimination ...
Bronner, Marianne E. +5 more
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Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches [PDF]
, 2014 Intraembryonic hematopoiesis occurs at two different sites, the floor of the aorta and subaortic patches (SAPs) of the para-aortic splanchnopleura (P-Sp)/aorta-gonad-mesonephros (AGM) region. Notch1 and RBP-j??
Yoon, Mi-Jeong +7 more
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Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade
eLife, 2019 Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus (SV)
Stanislao Igor Travisano +9 more
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The Effect of DNA Methylation on TP73 Expression in Tumorgenesis [PDF]
, 2018 : The Effect of DNA Methylation on TP73 Expression in Tumorgenesis Nujuma Moussa, Zhixing Yao, Zaki A. Sherif Department of Biochemistry & Molecular Biology, Howard University College of Medicine TP73 is a member of the TP53 family of proteins that acts ...
Moussa, Nujuma A
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Frontiers in ImmunologyIntroductionIncreasing evidence suggests that microvascular dysregulation mediates mesangial cell (MC) alteration in the pathogenesis of LN (Lupus nephritis).
Haixia Guo +7 more
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Identifying Behavioral Phenotypes and Heterogeneity in Heart Valve Surface Endothelium [PDF]
, 2016 Heart valvular endothelial cells (VECs) are distinct from vascular endothelial cells (ECs), but have an uncertain context within the spectrum of known endothelial phenotypes, including lymphatic ECs (LECs).
Acosta, Francisca M. +3 more
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Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
Vascular Cell, 2011 Tumor angiogenesis is an important target for cancer therapy, with most current therapies designed to block the VEGF signaling pathway. However, clinical resistance to anti-VEGF therapy highlights the need for targeting additional tumor angiogenesis signaling pathways.
Kuhnert, Frank +2 more
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Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]
, 2013 Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
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Diabetes, Metabolic Syndrome and Obesity, 2022 Na Gao,1,* Linghui Xiao,1,* Zheng Tao,2 Yanlin Zheng,1 Wanjie Wang,1 Hui Huang1 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of China; 2Eye College, Chengdu University of ...
Gao N +5 more
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