Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
Vascular Cell, 2011 Tumor angiogenesis is an important target for cancer therapy, with most current therapies designed to block the VEGF signaling pathway. However, clinical resistance to anti-VEGF therapy highlights the need for targeting additional tumor angiogenesis signaling pathways.
Kuhnert, Frank +2 more
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Correlation between pre-operative VE-cadherin and DLL4 and the maturation after primary arteriovenous fistula in uremic patients [PDF]
PeerJAims Uremic patients require dialysis to replace the declined kidney function, and arteriovenous fistula (AVF) is a commonly used dialysis access route. Our study aimed to explore vascular endothelial cells cadherin (VE-cadherin) and Delta-like ligand 4 (
Huanhuan Yin +5 more
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Multi-instanton calculus in N=2 supersymmetric QCD [PDF]
, 1996 Microscopic tests of the exact results are performed in N=2 SU(2) supersymmetric QCD. We construct the multi-instanton solution in N=2 supersymmetric QCD and calculate the two-instanton contribution ${\cal F}_2$ to the prepotential ${\cal F}$ explicitly.
't Hooft +32 more
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The Effect of DNA Methylation on TP73 Expression in Tumorgenesis [PDF]
, 2018 : The Effect of DNA Methylation on TP73 Expression in Tumorgenesis Nujuma Moussa, Zhixing Yao, Zaki A. Sherif Department of Biochemistry & Molecular Biology, Howard University College of Medicine TP73 is a member of the TP53 family of proteins that acts ...
Moussa, Nujuma A
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Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells [PDF]
, 2014 Human pluripotent stem cell (hPSC)-derived endothelial lineage cells constitutes a promising source for therapeutic revascularization, but progress in this arena has been hampered by a lack of clinically-scalable differentiation protocols and inefficient
Chien, Kenneth R +5 more
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Diabetes, Metabolic Syndrome and Obesity, 2022 Na Gao,1,* Linghui Xiao,1,* Zheng Tao,2 Yanlin Zheng,1 Wanjie Wang,1 Hui Huang1 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of China; 2Eye College, Chengdu University of ...
Gao N +5 more
doaj
Translational Oncology, 2018 The Notch signaling pathway has been identified as a therapeutic target for cancers. γ-Secretase inhibitors (GSIs) have been progressively recognized as potential anticancer drugs.
Muxing Kang +9 more
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Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche [PDF]
, 2019 Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific identities of macrophages in their respective niches. Using conditional depletion of liver Kupffer cells,
Beschin, Alain +22 more
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The role of Notch receptors and ligands in regulation of immune responses [PDF]
, 2012 Notch signalling has an important role in the immune system in directing cell fate decisions in a range of diverse cell types. We are beginning to obtain a better understanding of the roles that the different Notch ligands and receptors play in both ...
Hoyne, Gerard F
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High-resolution 3D analysis of mouse small-intestinal stroma. [PDF]
, 2016 Here we detail a protocol for whole-mount immunostaining of mouse small-intestinal villi that can be used to generate high-resolution 3D images of all gut cell types, including blood and lymphatic vessel cells, neurons, smooth muscle cells, fibroblasts ...
A Sabine +30 more
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