Results 121 to 130 of about 15,452 (227)

Correlation between pre-operative VE-cadherin and DLL4 and the maturation after primary arteriovenous fistula in uremic patients [PDF]

PeerJ
Aims Uremic patients require dialysis to replace the declined kidney function, and arteriovenous fistula (AVF) is a commonly used dialysis access route. Our study aimed to explore vascular endothelial cells cadherin (VE-cadherin) and Delta-like ligand 4 (
Huanhuan Yin, Yifan Tang, Yanping Wang, Yousuf Abdulkarim Waheed, Disheng Wang, Dong Sun   +5 more
doaj   +2 more sources

Notch signaling during human T cell development [PDF]

, 2012
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy, A Krueger, A Sambandam, A Wilson, A Wolfer, AC Jaleco, AI Garbe, AP Weng, B Blom, B Reizis, B Vandekerckhove, BN Weber, C Benne, CC Tydell, CN Ting, D Hockemeyer, D Hockemeyer, E Robey, EM Six, ES David-Fung, F Klein, F Radtke, F Radtke, F Timmermans, F Weerkamp, F Weerkamp, G Awong, H Hirata, H Neves, H Wang, HT Petrie, HY Kueh, I Hoebeke, I Maillard, I Maillard, I Walle Van de, I Walle Van de, J Buer, J Gotter, J Plum, J Shi, JS Yuan, K Heinzel, K Hozumi, K Li, K Maki, K Tanigaki, L Li, M Ciofani, M Ciofani, M Ciofani, M Garcia-Peydro, M Ghisi, M Magri, M Smedt De, M Smedt De, M Smedt De, M Smedt De, MA Yui, MD Green, ML Joachims, N Lefort, P Beatus, P Doerfler, P Li, QL Hao, QL Hao, R Haddad, RN Motte-Mohs La, S Coppernolle Van, S Doulatov, S Gonzalez-Garcia, S Suliman, S Verbeek, SK Durum, SK Ye, SM Lehar, SY Lee, T Hosoya, T Ikawa, T Ikawa, T Kreslavsky, T Kreslavsky, T Palomero, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, TB Feyerabend, TM Schmitt, TN Taghon, W Dontje, WA Dik, Y Wu, YR Carrasco, Z Galic   +97 more
core   +2 more sources

Concurrent Treatment with Anti-DLL4 Enhances Antitumor and Proapoptotic Efficacy of a γ-Secretase Inhibitor in Gastric Cancer

Translational Oncology, 2018
The Notch signaling pathway has been identified as a therapeutic target for cancers. γ-Secretase inhibitors (GSIs) have been progressively recognized as potential anticancer drugs.
Muxing Kang, Yaoyi Zhang, Xiaoli Jin, Guofeng Chen, Yi Huang, Dan Wu, Guogang Li, Jianzhen Shan, Pintong Huang, Jian Chen   +9 more
doaj   +1 more source

VEGFR-3 signaling regulates triglyceride retention and absorption in the intestine [PDF]

, 2018
The lymphatic system transports dietary lipids absorbed and packaged as chylomicrons by enterocytes, for delivery to the bloodstream. Once considered a passive drainage, chylomicron entry into intestinal lymphatic vessels, or lacteals, is now emerging to
Cifarelli, Vincenza, Shew, Trevor, Wolins, Nathan E   +2 more
core   +2 more sources

The role of Notch receptors and ligands in regulation of immune responses [PDF]

, 2012
Notch signalling has an important role in the immune system in directing cell fate decisions in a range of diverse cell types. We are beginning to obtain a better understanding of the roles that the different Notch ligands and receptors play in both ...
Hoyne, Gerard F
core   +2 more sources

Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis

Journal of Neuroinflammation
Under neuroinflammatory conditions, astrocytes acquire a reactive phenotype that drives acute inflammatory injury as well as chronic neurodegeneration.
Pierre Mora, Margaux Laisné, Célia Bourguignon, Paul Rouault, Béatrice Jaspard-Vinassa, Marlène Maître, Alain-Pierre Gadeau, Marie-Ange Renault, Sam Horng, Thierry Couffinhal, Candice Chapouly   +10 more
doaj   +1 more source

DLL4-targeted CAR-T therapy sensitizes neoadjuvant chemotherapy via eliminating cancer stem cells and reshaping immune microenvironment in HER2+ breast cancer

Journal for ImmunoTherapy of Cancer
Background Neoadjuvant therapy with trastuzumab, pertuzumab and paclitaxel (THP) has significantly improved the prognosis of patients with human epidermal growth factor receptor 2 (HER2)+ breast cancer (BC).
Tianxing Zhou, Yongjie Xie, Yanfang Yang, Ziyun Liu, Jingrui Yan   +4 more
doaj   +1 more source

DLL4 Gene [PDF]

, 2020
openaire   +1 more source

DLL4 wt Allele [PDF]

, 2020
openaire   +1 more source

Correlation between serum level of Delta Like Ligand 4 and different types of Diabetic Retinopathy and Maculopathy in Egyptian patients

Journal of the Egyptian Ophthalmological Society
Objectives Delta-like ligand-4 (DLL4) is responsible for normal physiological and pathological retinal vasculature. In this study, we aim to compare DDL4 serum levels in both healthy and diabetic patients.
Mohamed A.R. Rady, Hany ElMekawey, Marwa ElSharkawy, Shaymaa H. Salah   +3 more
doaj   +1 more source