Results 141 to 150 of about 10,120 (171)

Targeting DLL4 in Tumors Shows Preclinical Activity But Potentially Significant Toxicity

Future Oncology, 2010
Evaluation of: Yan M, Callahan CA, Beyer JC et al.: Chronic DLL4 blockade induces vascular neoplasms. Nature 463, E6-E7 (2010). Delta-like ligand 4 (DLL4) is a Notch ligand that is critical in the formation of a functional vascular network in tumors ...
Ji-Liang Li, Adrian M Jubb, Adrian L Harris   +2 more
exaly   +2 more sources

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The Prediction of DLL4 as a Prognostic Biomarker in Patients with Gastric Cancer Using Anti-DLL4 Nanobody

Journal of Gastrointestinal Cancer
Angiogenesis and cancer metastasis depend on the DLL4/Notch signaling pathway. A new approach to treating angiogenesis could inhibit or block this pathway. In the present study, we investigated DLL4 expression as a biomarker capable of predicting survival outcomes in gastric cancer patients using a novel anti-DLL4 Nanobody.By using a recently developed
Reza Afzalipour, Maryam Mohammadlou, Rasoul Baharlou   +2 more
exaly   +3 more sources

The Clinicopathological Significance of Jagged1 and DLL4 in Gallbladder Cancer

Tumori Journal, 2016
Purpose Gallbladder cancers (GBCs) are highly aggressive gastrointestinal cancers with high mortality. Biological markers for the diagnosis, prognosis, and targeted therapy of GBCs have not been established. Methods The protein expression of Jagged1 and DLL4 in 80 adenocarcinomas (AC) and 46 squamous cell/adenosquamous carcinomas (SC/ASCs) was measured
Yuan, Luo, Zhu-Lin, Yang, Chunwei, Wang, Xiongying, Miao, Zhiyu, Liu, Daiqiang, Li, Qiong, Zou, Jinghe, Li, Lufeng, Liang, Guixiang, Zeng, Senlin, Chen   +10 more
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Dll4-Notch signaling in regulation of tumor angiogenesis

Journal of Cancer Research and Clinical Oncology, 2013
Tumor angiogenesis is a complex process and involves the tight interplay of tumor cells, endothelial cells, phagocytes and their secreted factors, which may act as promoters or inhibitors of angiogenesis. Many signaling pathways involved in these processes such as vascular endothelial growth factor (VEGF), fibroblast growth factors, Wnt and mTOR ...
Zhaoguo, Liu, Fangtian, Fan, Aiyun, Wang, Shizhong, Zheng, Yin, Lu   +4 more
openaire   +2 more sources

Chronic DLL4 blockade induces vascular neoplasms

Nature, 2010
Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising ...
Minhong, Yan, Christopher A, Callahan, Joseph C, Beyer, Krishna P, Allamneni, Gu, Zhang, John Brady, Ridgway, Kyle, Niessen, Greg D, Plowman   +7 more
openaire   +2 more sources

Expression pattern of Dll4 during chick embryogenesis

Histochemistry and Cell Biology, 2007
Notch and Delta signaling regulates cell-fate decisions in a variety of tissues in diverse organisms through cell-to-cell interactions. In this study we isolated a 696 bp fragment of chick Delta-like 4 (Dll4) cDNA and analyzed its expression pattern during chick development by in situ hybridization.
Nimmagadda, Suresh, Geetha Loganathan, Poongodi, Pröls, Felicitas, Scaal, Martin, Christ, Bodo, Huang, Ruijin   +5 more
openaire   +3 more sources

Dll1 and Dll4: similar, but not the same

Blood, 2009
The VEGF-Dll4-Notch1 signaling cascade has taken center stage in angiogenesis, but it now appears that Dll1 ligands have precedence in arteries and even seem to control VEGF signaling.
openaire   +2 more sources

Abstract A19: Potent antitumor activity of Dll4 blockade in ovarian xenografts mediated by blocking stromal Dll4

Molecular Cancer Therapeutics, 2015
Abstract The Notch ligand delta-like 4 (Dll4) has been identified as a promising new target in tumor angiogenesis in preclinical studies, and Dll4 inhibitors have recently entered clinical trials for solid tumors, including ovarian cancers.
Frank Kuhnert, Guoying Chen, Sandra Coetzee, Jessica Kirshner, Gavin Thurston   +4 more
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Dll4: “Notch” Your Normal Pathway

The FASEB Journal, 2017
The rising threat of nuclear terrorism necessitates proactive research to mitigate injury by radiation. Since one of the most damaging effects of radiation is the reduction of small blood vessels in healthy tissue, radiation‐induced organ damage may be lessened by increasing blood vessel density.
Emily Barmantje, Erica Nelson, Aayush Agrawal, Smrithi Chanjeevaram, Aditya Jhaveri, Michelle Lazar, Katrina Li, Darby McManus, Nikhita Santebennur, Mia Schlidt, Meetha Medhora   +10 more
openaire   +1 more source

DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27 KIP1 and Thrombospondin-1

Arteriosclerosis, Thrombosis, and Vascular Biology, 2015
OBJECTIVE: Bone morphogenetic protein-9 (BMP9)/activin-like kinase-1 and delta-like 4 (DLL4)/Notch promote endothelial quiescence, and we aim to understand mechanistic interactions between the 2 pathways.
Bahman Rostama, Thomas Gridley, Calvin P H Vary   +2 more
exaly   +1 more source