Results 151 to 160 of about 10,120 (171)
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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
Nature, 2006Haploinsufficiency of Dll4, a vascular-specific Notch ligand, has shown that it is essential for embryonic vascular development and arteriogenesis. Mechanistically, it is unclear how the Dll4-mediated Notch pathway contributes to complex vascular processes that demand meticulous coordination of multiple signalling pathways.
John, Ridgway +16 more
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The expression of VEGF and Dll4/Notch pathway molecules in ovarian cancer
Clinica Chimica Acta, 2014VEGF and Dll4/Notch pathways play important roles in tumor angiogenesis. The purpose of this study is to investigate the expression of these two pathway molecules in ovarian cancer and their possible relationships in carcinogenesis.Twenty-eight specimens of human ovarian carcinoma, 18 of benign ovarian and 20 of healthy ovarian tissues were subjected ...
Na Shao, Chunyan Ji
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Journal of Pharmacological and Toxicological Methods, 2016
Rene Meisner +6 more
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Rene Meisner +6 more
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VEGF/DLL4 BINDING AGENTS AND USES THEREOF
2019The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind ...
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Low HES-1 and positive DLL4 expression predicts poor prognosis of colorectal cancers
Pathology, 2023Gilhyang Kim +2 more
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The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
Nature Reviews Cancer, 2007George D Yancopoulos +2 more
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