Results 11 to 20 of about 15,452 (227)
Clinical implications of DLL4 expression in gastric cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2013 BACKGROUND: Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been clarified.
Akihiro Nakajo +13 more
core +4 more sources
Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis. [PDF]
Adv Sci (Weinh)Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Kim B +16 more
europepmc +2 more sources
Therapeutic promise and challenges of targeting DLL4/NOTCH1 [PDF]
Vascular Cell, 2011 DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade.
Minhong Yan
core +4 more sources
EHD2 modulates Dll4 endocytosis during blood vessel development [PDF]
Microcirculation, 2021 AbstractObjectiveDespite the absolute requirement of Delta/Notch signaling to activate lateral inhibition during early blood vessel development, many mechanisms remain unclear about how this system is regulated. Our objective was to determine the involvement of Epsin 15 Homology Domain Containing 2 (EHD2) in delta‐like ligand 4 (Dll4) endocytosis ...
Amelia M. Webb +7 more
openaire +2 more sources
Endothelial Jagged1 Antagonizes Dll4 Regulation of Endothelial Branching and Promotes Vascular Maturation Downstream of Dll4/Notch1 [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 Objective— Notch signaling controls cardiovascular development and has been associated with several pathological conditions. Among its ligands, Jagged1 and Dll4 were shown to have opposing effects in developmental angiogenesis, but the underlying mechanism and the role of Jagged1/Notch signaling in adult angiogenesis remain ...
Ana-Rita, Pedrosa +9 more
openaire +2 more sources
Dll4/Notch Signaling Pathway and Tumor Angiogenesis [PDF]
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2009 Xinyu DING, Zhifei XU
core +3 more sources
Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis [PDF]
Circulation Research, 2020 Rationale: Central nervous system has low vascular permeability by organizing tight junction (TJ) and limiting endothelial transcytosis. While TJ has long been considered to be responsible for vascular barrier in central nervous system, suppressed transcytosis in endothelial cells is now emerging as a complementary mechanism ...
Jee Myung Yang +22 more
openaire +3 more sources
JCI Insight, 2021 The molecular mechanisms by which endothelial cells (ECs) regulate pulmonary vascularization and contribute to alveolar epithelial cell development during lung morphogenesis remain unknown.
Sheng Xia +8 more
doaj +1 more source
Influence of Dll4 via HIF-1α-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions. [PDF]
PLoS ONE, 2011 Choroidal neovascularization (CNV) is the common pathological basis of irreversible visual impairment encountered in a variety of chorioretinal diseases; the pathogenesis of its development is complicated and still imperfectly understood.
Xiao Dong +10 more
doaj +1 more source
Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium
Frontiers in Immunology, 2022 T-cell development in the thymus is dependent on Notch signaling induced by the interaction of Notch1, present on immigrant cells, with a Notch ligand, delta-like (Dll) 4, on the thymic epithelial cells.
Ken-ichi Hirano +15 more
doaj +1 more source