Clinical implications of DLL4 expression in gastric cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2013 BACKGROUND: Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been clarified.
Akihiro Nakajo +13 more
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EHD2 modulates Dll4 endocytosis during blood vessel development [PDF]
Microcirculation, 2021 AbstractObjectiveDespite the absolute requirement of Delta/Notch signaling to activate lateral inhibition during early blood vessel development, many mechanisms remain unclear about how this system is regulated. Our objective was to determine the involvement of Epsin 15 Homology Domain Containing 2 (EHD2) in delta‐like ligand 4 (Dll4) endocytosis ...
Amelia M. Webb +7 more
openaire +2 more sources
Endothelial Jagged1 Antagonizes Dll4 Regulation of Endothelial Branching and Promotes Vascular Maturation Downstream of Dll4/Notch1 [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 Objective— Notch signaling controls cardiovascular development and has been associated with several pathological conditions. Among its ligands, Jagged1 and Dll4 were shown to have opposing effects in developmental angiogenesis, but the underlying mechanism and the role of Jagged1/Notch signaling in adult angiogenesis remain ...
Ana-Rita, Pedrosa +9 more
openaire +2 more sources
Dll4/Notch Signaling Pathway and Tumor Angiogenesis [PDF]
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2009 Xinyu DING, Zhifei XU
core +3 more sources
Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis [PDF]
Circulation Research, 2020 Rationale: Central nervous system has low vascular permeability by organizing tight junction (TJ) and limiting endothelial transcytosis. While TJ has long been considered to be responsible for vascular barrier in central nervous system, suppressed transcytosis in endothelial cells is now emerging as a complementary mechanism ...
Jee Myung Yang +22 more
openaire +3 more sources
Influence of Dll4 via HIF-1α-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions. [PDF]
PLoS ONE, 2011 Choroidal neovascularization (CNV) is the common pathological basis of irreversible visual impairment encountered in a variety of chorioretinal diseases; the pathogenesis of its development is complicated and still imperfectly understood.
Xiao Dong +10 more
doaj +1 more source
Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. [PDF]
, 2016 BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Chuang, Yung-Jen +6 more
core +2 more sources
JCI Insight, 2021 The molecular mechanisms by which endothelial cells (ECs) regulate pulmonary vascularization and contribute to alveolar epithelial cell development during lung morphogenesis remain unknown.
Sheng Xia +8 more
doaj +1 more source
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]
, 2012 Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson +79 more
core +1 more source
Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. [PDF]
, 2018 Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how
Ablooglu, Ararat J +6 more
core +3 more sources