Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer
Technology in Cancer Research & Treatment, 2023 Background : Notch signaling played a critical role in promoting breast tumorigenesis and progression. However, the role and prognostic value of Notch3 combined with DLL4 expression in breast carcinoma had not been explored.
Lin Wang +9 more
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Biomaterial-based ligand presentation to induce notch signaling in vitro [PDF]
, 2013 T cell adoptive transfer is an important procedure in immunotherapy. In immunocompromised patients, T cells may need to be developed from stem cells, requiring the induction of Notch signaling events responsible for native T cell differentiation in the ...
Mehta, Naveen
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Dll4, a novel Notch ligand expressed in arterial endothelium [PDF]
Genes & Development, 2000 We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding.
J R, Shutter +7 more
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Stem Cell Research, 2016 Studies with different animal models have shown that the Notch ligand DLL4 has a key role in the development of the embryonic vasculature. Here we describe the generation and characterization of a human embryonic stem cell line and an induced pluripotent
Federico González-Pozas +7 more
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DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. [PDF]
, 2015 The small intestine is a dynamic and complex organ that is characterized by constant epithelium turnover and crosstalk among various cell types and the microbiota.
Barker +23 more
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Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]
, 2016 The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita +5 more
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Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production. [PDF]
PLoS ONE, 2013 The Notch pathway plays a role in the processes of cell proliferation, differentiation, and apoptosis, which affect the development and function of various organs.
Huei-Mei Huang +6 more
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Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.: DLL4's opposing effects in choroidal neovascularization [PDF]
, 2012 International audienceInflammatory neovascularization, such as choroidal neovascularization (CNV), occur in the presence of Notch expressing macrophages. DLL4s anti-angiogenic effect on endothelial cells (EC) has been widely recognized, but its influence
Calippe, Bertrand +16 more
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The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
PLoS ONE, 2012 BackgroundIn mouse embryos, homozygous or heterozygous deletions of the gene encoding the Notch ligand Dll4 result in early embryonic death due to major defects in endothelial remodeling in the yolk sac and embryo.
Ricardo Laranjeiro +8 more
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Association of Dll4/notch and HIF-1a -VEGF signaling in the angiogenesis of missed abortion. [PDF]
PLoS ONE, 2013 Dll4/Notch and HIF-1a-VEGF have been shown to play an important role during angiogenesis, but there are no data about their roles and association in missed abortion.
Yan Fang +6 more
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