Results 61 to 70 of about 15,452 (227)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Hydroxytyrosol protects isoproterenol-induced myocardial infarction through activating notch signaling [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): In this investigation, the protective effects of hydroxytyrosol (HT) administered prior to myocardial infarction in rats were examined, with a particular focus on its potential roles within the Notch pathway.Materials and Methods: The ...
Elif Onat, Ahmet Türk, Nevin Kocaman, Serhat Hançer, Solmaz Susam, Ali Parlar, Selin Turhan, Mehmet Ozer   +7 more
doaj   +1 more source

Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

iScience, 2022
Summary: Spatial regulation of angiogenesis is important for the generation of functional engineered vasculature in regenerative medicine. The Notch ligands Jag1 and Dll4 show distinct expression patterns in endothelial cells and, respectively, promote ...
Laura A. Tiemeijer, Tommaso Ristori, Oscar M.J. A. Stassen, Jaakko J. Ahlberg, Jonne J.J. de Bijl, Christopher S. Chen, Katie Bentley, Carlijn V.C. Bouten, Cecilia M. Sahlgren   +8 more
doaj   +1 more source

The significance of Notch ligand expression in the peripheral blood of children with hand, foot and mouth disease (HFMD) [PDF]

, 2014
BACKGROUND: Hand, foot and mouth disease (HFMD), a virus-induced infectious disease that usually affects infants and children, has an increased incidence in China in recent years.
Bai, Zhen Jiang, Huang, Jie, Kong, Xiao Xing, Li, Yi Ping, Lu, Chun Yu, Tian, Jian Mei, Wang, Jian, Wang, Jiang Huai, Xiang, Yong Jun   +8 more
core   +2 more sources

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

eLife, 2016
Formation of a regularly branched blood vessel network is crucial in development and physiology. Here we show that the expression of the Notch ligand Dll4 fluctuates in individual endothelial cells within sprouting vessels in the mouse retina in vivo and
Benedetta Ubezio, Raquel Agudo Blanco, Ilse Geudens, Fabio Stanchi, Thomas Mathivet, Martin L Jones, Anan Ragab, Katie Bentley, Holger Gerhardt   +8 more
doaj   +1 more source

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]

, 2019
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud, Kerr, Matthew D, Mao, Angelo S, Mooney, David J, Raimondo, Theresa M, Scadden, David T, Shah, Nisarg J, Sharda, Azeem, Shih, Ting-Yu, Tager, Andrew M, Vrbanac, Vladimir D, Weaver, James C   +11 more
core   +1 more source