Results 111 to 120 of about 35,348 (219)

Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR‐F508del Rabbit Model

International Forum of Allergy &Rhinology, Volume 16, Issue 8, Page 788-796, August 2026.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk ...
Do‐Yeon Cho, Alexis E. McFeely, Daniel Skinner, Shaoyan Zhang, Justin Hedvat, Weslee Ping‐ay, Daniel M. Beswick, Justin H. Turner, Bradford A. Woodworth, Jie Xu   +9 more
wiley   +1 more source

Phytochemical Composition, In Vitro Antioxidant, Antibacterial, and Antibiofilm Activities of Thymus vulgaris Essential Oil From Tiaret, Algeria

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Thymus vulgaris essential oil (TvEO), largely composed of thymol, showed strong bactericidal activity with Staphylococcus aureus (S. aureus) being most sensitive. TvEO markedly inhibited MRSA biofilm formation and significantly reduced established biofilms. Molecular docking suggests several TvEO components interact with proteins involved in S.
Soumia Dakhouche, Mouna Mnif, Sami Mnif
wiley   +1 more source

Exploration of the Substrate Diversity of the Amine Transaminase 3FCR‐4M and its Engineered Variants

ChemCatChem, Volume 18, Issue 15, 14 August 2026.
We evaluated combinatorial variants of the engineered amine transaminase 3FCR‐4M in both kinetic resolution and asymmetric synthesis. This dual assessment revealed a striking discrepancy between high kinetic resolution activity and low asymmetric synthesis conversion, reflecting the inherent kinetic favorability of the deamination half‐reaction and ...
Konstantin F. G. Weigmann, Nils Michels, Mark Doerr, Uwe T. Bornscheuer   +3 more
wiley   +1 more source

Intranasal Administration of an Arginine‐Enriched Penetratin Peptide Confers Neuroprotection via Mitochondrial Functional Modulation in a Genetic Parkinson's Disease Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Intranasal PenArg achieved broad brain delivery and improved mitochondrial function in a UQCRC1‐mutant Parkinson's disease model. Chronic treatment preserved dopaminergic neurons, improved motor performance, reduced neuroinflammatory and systemic inflammatory responses, and attenuated skeletal muscle pathology.
Jui‐Chih Chang, Cheng‐Yi Yeh, Kai‐Li Liu, Yi‐Chun Chao, Chin‐Hsien Lin, Chin‐San Liu   +5 more
wiley   +1 more source

Structure-activity relationship study shows versatility in substrate specificity for heterodisulfide reductase in methanogenic archaea. [PDF]

Protein Sci
Maleki MF, Jakobsen JB, Schuiten ED, Wagner T, Neves ALA, Bunch L.   +5 more
europepmc   +1 more source

Two Novel 1,4‐Naphthoquinone Derivatives as Potent Agents Against Multidrug‐Resistant Staphylococcus aureus and Pathogenic Gram‐Positive Bacteria

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Drug‐resistant bacteria such as Methicillin‐resistant Staphylococcus aureus (MRSA) and Quinolone‐resistant S. aureus (QRSA), are a growing problem, creating a need for the development of novel antimicrobial agents. In this study, we designed and synthesized two novel 1,4‐naphthoquinone derivatives, LHN‐1034 and LHN‐1035, and evaluated their ...
HyunChan Song, Haena Lee, Ji‐Hyun Yoon, Hyunkyung Choi, Hakwon Kim, Ki‐Young Kim   +5 more
wiley   +1 more source

1,2,3-Benzoxathiazine-2,2-Dioxides as Inhibitors of Thioredoxin Reductase. [PDF]

ChemMedChem
Ivanova J, Jackeviča L, Sizovs A, Bobrovs R, Žalubovskis R.   +4 more
europepmc   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Selective Anti-Giardial Action of Indirubin: Biochemical and Functional Evidence for Inhibition of Triosephosphate Isomerase and Aldose Reductase in <i>Giardia lamblia</i>. [PDF]

Int J Mol Sci
Flores-López LA, López-Herrera G, Martínez-Pérez Y, Matadamas-Ortiz EJ, Gómez-Manzo S, Hernández-Alcántara G, González-Maciel A, Reynoso-Robles R, Hernández-Ochoa B, Chino-Ríos L, González-Gómez D, Arteaga-Padilla LV, Enríquez-Flores S, De la Mora-de la Mora I.   +13 more
europepmc   +1 more source

Methotrexate Alters Nrf2/HO‐1 Protein Expression and Intrinsic Apoptosis‐Associated Protein Responses in OVCAR‐3 Ovarian Cancer Cells: Differential Modulation by Antioxidant Compounds

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Methotrexate (MTX) altered oxidative stress parameters, reduced Nrf2 and HO‐1 protein expression, increased intrinsic apoptosis‐associated protein markers, and decreased cell viability in OVCAR‐3 cells. Antioxidant co‐treatment partially modulated these protein responses and oxidative stress parameters.
Oya Korkmaz
wiley   +1 more source