Results 141 to 150 of about 35,348 (219)

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Structure and function of periplasmic nitrate reductase. [PDF]

Biochem Soc Trans
Mongkonpruthangkoon C, Giri NC, Basu P.
europepmc   +1 more source

DNA Methylation Shapes Seed‐Borne Microbiome and Proteome Responses During Early Maize‐Beneficial Bacteria Interactions

Plant, Cell &Environment, Volume 49, Issue 8, Page 5477-5496, August 2026.
ABSTRACT Microorganism and plant interactions are crucial for development and environmental adaptation. Plant growth promoting bacteria enhance agricultural productivity in a sustainable manner, while epigenetic modifications such as DNA methylation regulate gene expression and adaptive responses.
Pedro Igor Zocateli, Geovanna Vitória Olímpio, Felipe Astolpho de Almeida, Letícia Oliveira da Rocha, Diego Vinicius de Sena Martins, Sara Sangi, Fábio Lopes Olivares, Elyabe Monteiro de Matos, Juliana Siqueira, Lyderson Facio Viccini, Roberta Pena da Paschoa, Vanildo Silveira, Clícia Grativol   +12 more
wiley   +1 more source

Secondary metabolites from <i>Lobaria pulmonaria</i> (L.) Hoffm. target key metabolic enzymes: a novel strategy against multidrug-resistant tuberculosis. [PDF]

RSC Adv
Nguyen HT, Badavath VN, Maji S, Polimati H, Okello E, Bunce RA, Thuan NH, Nuzul Hakimi Wan Salleh WM, Tatipamula VB.   +8 more
europepmc   +1 more source

Mitochondria limit coenzyme Q export under cholesterol biosynthetic stress. [PDF]

J Cell Biol
Ndoci M, Bhattacharya S, Agrawal I, Hinze Y, Lemke K, Schumacher AL, Uijttewaal E, Elling U, Lawo S, Giavalisco P, Langer T, Deshwal S.   +11 more
europepmc   +1 more source

Using Domain Insertion to Create Sulfite Reductases That Present Chemical-Dependent Activities. [PDF]

ACS Synth Biol
Windham E, Myerscough D, Schwartz SK, Carpenter MD, Ajo-Franklin CM, Silberg JJ.   +5 more
europepmc   +1 more source

Alcohol Oxidase-Imine Reductase Cascade for One-Pot Chiral Amine Synthesis. [PDF]

ACS Catal
Miletic A, Truby CJ, Turner NJ, Ruscoe RE.   +3 more
europepmc   +1 more source

Investigating the role of bacterial raw milk community members in chlorate reduction. [PDF]

Access Microbiol
Srinivas M, O'Sullivan O, Cotter PD, van Sinderen D, Kenny JG.   +4 more
europepmc   +1 more source

Lichen Extracts Containing Volatile Compounds Induce Oxidative Stress and Modulate the Growth of <i>Microcystis aeruginosa</i> and <i>Chlorella sorokiniana</i>. [PDF]

Int J Mol Sci
Essadki Y, Darrag EM, Zerrifi SEA, Haida M, Krimech A, Martins R, Campos A, Vasconcelos V, Bouaïcha N, Baçaoui A, Meddich A, Oudra B, Tazart Z, Khalloufi FE.   +13 more
europepmc   +1 more source

Novel Synthetic Steroid Derivatives: Target Prediction and Biological Evaluation of Antiandrogenic Activity. [PDF]

Curr Issues Mol Biol
Calderón Guzmán D, Osnaya Brizuela N, Juárez Olguín H, Ortiz Herrera M, Valenzuela Peraza A, Hernández Garcia E, Chávez Riveros A, Calderón Morales S, Rojas Ochoa A, Silva Ortiz A, Santes Palacios R, Dorado Gonzalez VM, García Ortega D.   +12 more
europepmc   +1 more source