Results 141 to 150 of about 202,224 (260)
Protein Science, Volume 35, Issue 11, November 2026.Abstract Eukaryotic proteomes are regulated by the ubiquitin‐proteasome system. Unwanted proteins are tagged with ubiquitin, which is recognized by the 26S proteasome for degradation. To enter the proteasome's 20S core particle and be hydrolyzed into peptides, the substrate must be unfolded and threaded through the 19S regulatory particle.
Edwin R. Ragwan +4 more
wiley +1 more source
Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos +4 more
wiley +1 more source
Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications
Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika +9 more
wiley +2 more sources
Elucidating the Molecular Impact of DA29‐Induced ClpP Chemoactivation on Mitochondrial Function
The FASEB Journal, Volume 40, Issue 20, 31 October 2026.A promising approach to tackling DIPG, a lethal pediatric brain tumor, relies on small molecules capable of activating the human mitochondrial protease hClpP. The novel piperazine‐based compound DA29 specifically activates endogenous hClpP, thereby compromising mtDNA levels, mitoribosomes, and OXPHOS complex subunits.
Francesca Rizzo +5 more
wiley +1 more source
Periplasmic nitrate reductase catalytic subunit (NapA) belongs to the DMSO reductase (DMSOR) family of molybdenum cofactor (Moco) containing enzymes and catalyzes nitrate reduction to nitrite.
Wedasingha, Lahiru +4 more
core +1 more source
Recent Progress in Understanding the Mechanism of Formate Dehydrogenases
ChemBioChem, Volume 27, Issue 19, 14 October 2026.A hydride transfer mechanism for the molybdenum‐ and tungsten‐containing formate dehydrogenases. Recent work concerning the reaction mechanism of the molybdenum‐containing formate dehydrogenases is discussed, focusing on two alternate mechanisms of action for the enzyme involving either formation of CO2 or bicarbonate as the immediate product of the ...
Russ Hille, Dimitri Niks
wiley +1 more source
Construction of Enantioselective Sulfoxide Sensor Using DMSO Reductase
Analytical Sciences/Supplements, 2002 ABO, Mitsuru +5 more
openaire +1 more source
Advances in the DMSO reductase family: From discovery to mechanism. [PDF]
Curr Opin Chem BiolGiri NC, Basu P.
europepmc +1 more source
Advanced Science, Volume 13, Issue 57, 14 October 2026.A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang +5 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION Epigenetic dysregulation is increasingly linked to aging and neurodegeneration, yet its contribution to retinal and brain pathology in Alzheimer's disease (AD) remains unclear. METHODS We quantified the repressive epigenetic mark histone H3 lysine 9 trimethylation (H3K9me3) in post mortem retinas and brains from donors spanning ...
Dieu‐Trang Fuchs +20 more
wiley +1 more source