Results 61 to 70 of about 860,536 (318)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genome-specific association study (GSAS) for exploration of variability in hemp (Cannabis sativa)

Scientific Reports
Hemp (Cannabis sativa L.) is a versatile crop with substantial potential for creating productive, sustainable, and resilient agricultural systems.
Nina Trubanová, Sachiko Isobe, Kenta Shirasawa, Akiko Watanabe, George Kelesidis, Rainer Melzer, Susanne Schilling   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Power and limitations of environmental DNA metabarcoding for surveying leaf litter eukaryotic communities [PDF]

, 2020
Leaf litter habitats shelter a great variety of organisms, which play an important rolein ecosystem dynamics. However, monitoring species in leaf litter is challenging, especiallyin highly diverse environments such as tropical forests, because ...
Baêta, Délio, Carla Martins Lopes, Baptista Haddad, Célio Fernando, Taberlet, Pierre, Thais Sasso, Vanzetti, Agustín Iván, Vanzetti, A, Haddad, Célio Fernando Baptista [UNESP], Pierre Taberlet, Raquel Zamudio, K, Agustín Vanzetti, Baêta, Délio [UNESP], Lopes, CM, Délio Baêta, Célio Fernando Baptista Haddad, Sasso, T, Sasso, Thais, Baêta, D, Raquel Zamudio, Kelly, Martins Lopes, Carla, Vanzetti, Agustín, Kelly Raquel Zamudio, Lopes, Carla Martins [UNESP], Haddad, CFB, Taberlet, P   +24 more
core   +1 more source

Comparative Mitogenomic Analyses of Tanypodinae (Diptera: Chironomidae)

Insects
Tanypodinae, a highly diverse subfamily within Chironomidae (Diptera), has been poorly represented in mitochondrial genome (mitogenome) databases, with only a limited number of complete or partial sequences available.
Xiu-Ru Xiao, Meng-Han Chen, Shu-Yi Li, Bing-Xin Guo, Yan Zhang, Zhi-Chao Zhang, Ya-Jun Qiao, Xiao-Long Lin   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Low-Level Environmental Cadmium Exposure is Associated with DNA Hypomethylation in Argentinean Women. [PDF]

, 2012
Background: Cadmium, a common food pollutant, alters DNA methylation in vitro. Epigenetic effects might therefore partly explain cadmium's toxicity, including carcinogenicity, but human data on epigenetic effects are lacking.
Concha, Gabriela, Vahter, Marie, Broberg Palmgren, Karin, Marie Vahter, Broberg, K,, Vahter, M,, Hossain, MB, Gabriela Concha, Mohammad Bakhtiar Hossain, Concha, G, Broberg Palmgren, Karin,, Hossain, Mohammad Bakhtiar, Karin Broberg, Lund University.   +13 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Toxic Effects of Methylene Blue on the Growth, Reproduction and Physiology of Daphnia magna

Toxics, 2023
Methylene blue (MB) is a disinfectant used in aquaculture to prevent and treat fish diseases. However, the release of MB can pose a risk to the receiving water bodies. Zooplankton are the most sensitive organisms among aquatic life.
Shuhui Li, Yixin Cui, Min Wen, Gaohua Ji
doaj   +1 more source