Results 121 to 130 of about 479,747 (308)

Thymine DNA glycosylase as a novel target for melanoma [PDF]

, 2019
Melanoma is an aggressive neoplasm with increasing incidence that is classified by the NCI as a recalcitrant cancer, i.e., a cancer with poor prognosis, lacking progress in diagnosis and treatment.
Dorjsuren D. G., Devarajan K, Simeonov A., Giordano A, Devarajan K., Kadariya Y, Katz RA, Kadariya Y., Mancuso P., Katz R. A., Jelinek J, Cosentino L, Davidson I., Yen T. J., Tricarico R., Jelinek J., Cosentino L., Bhattacharjee V, Nicolas E, Davidson G., Sun H, Testa JR, Tricarico R, Sun H., Giordano A., Sobol RW, Nicolas E., Beeharry N, Dorjsuren DG, Einarson M., Larue L, Larue L., Testa J. R., Beeharry N., Einarson M, Davidson I, Bhattacharjee V., Bellacosa A., Davidson G, Yen TJ, Simeonov A, Sobol R. W., *Mancuso P, Bellacosa A (*co-first author)   +43 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

THE ATAXIA-TELANGIECTASIA MUTATED (ATM) GENE PLAYS A PIVOTAL ROLE IN THE REPAIR OF DNA IN CASES OF MYELODYSPLASTIC NEOPLASM

Myelodysplastic Neoplasm (MDS) is an age-associated neoplasia characterized by frequent epigenetic abnormalities being hypermethylation the most common, frequently associated with transformation to acute myeloid leukemia (AML). DNA repair genes have been
DP Borges, HLR Junior, PRC Passos, LR Sampaio, JVC Goes, RDB Dias, RTG Oliveira, CLA Araujo, RF Pinheiro, SMM Magalhães   +9 more
core   +1 more source

Diagnostic management of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in close interaction with therapeutic considerations. [PDF]

Blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare malignancy derived from plasmacytoid dendritic cells, can mimic both acute leukemia and aggressive T-cell lymphoma.
Pollak, Matthias, Legros, Myriam, Pabst, Thomas, Bacher, Vera, Künstner, Axel, Schliemann, Christoph, Banz, Yara, Kolloch, Lina, Haase, Detlef, Witte, Hanno, Mazzeo, Paolo, Beltraminelli, Helmut, Kerkhoff, Andrea, Lenz, Georg, Shumilov, Evgenii, Weidemann, Sören, Ghandili, Susanne, Feldmeyer, Laurence, Mikesch, Jan-Henrik, Wulf, Gerald, Gebauer, Niklas, Bacher, Ulrike, Ströbel, Philipp   +22 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

EWS::FLI1 expression in human embryonic mesenchymal stem cells leads to transcriptional reprograming, defective DNA damage repair and Ewing sarcoma

Nature Communications
Ewing sarcoma (ES) is an aggressive bone and soft tissue neoplasm characterized by EWSR::ETS rearrangements whose cellular origin remains unclear. EWS::FLI1 expression in human pediatric mesenchymal stem cells (MSCs) induces a transcriptional response ...
Inmaculada Hernández-Muñoz, Irene Cuervas, Estela Prada, Julian Pulecio, Ramón Gimeno, Evelyn Andrades, Soledad Gómez-González, Pau Berenguer-Molins, Ariadna Acedo-Terrades, Júlia Perera-Bel, Marta Bódalo-Torruella, Lara Nonell, Elena Pérez, Daniela Grases, Caterina Mata, José Yélamos, Yvonne Richaud-Patin, Enrique Vidal, Yasmina Cuartero, François Le Dily, Mariona Suñol, Alejandro Manzanares, Angel Raya, Jaume Mora   +23 more
doaj   +1 more source

Prognostic DNA Methylation Markers for Prostate Cancer

, 2014
Prostate cancer (PC) is the most commonly diagnosed neoplasm and the third most common cause of cancer-related death amongst men in the Western world.
Siri Strand, Karina Sorensen, Torben Orntoft   +2 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Mediating Effect of White Blood Cells and Tobacco Exposure on Cervical Neoplasm Risk Among Taiwanese Women

[[abstract]]Background: Both the high-risk human papillomavirus (HR-HPV) infection and tobacco exposure are significantly associated with cervical neoplasm risk. Immune cells play important roles in carcinogenesis.
Wang, Wei-Jun, Chang, Ching Wen, Shih, Ya Wen, Fang, Hui Fen, Tsai, Jia Ruey, Lin, Chia Ling, Chang, Hui-Chen Rita, Rias, Yohanes Andy, Tsai, Hsiu Ting   +8 more
core  

A comprehensive characterization of rare mitochondrial DNA variants in neuroblastoma

, 2016
Neuroblastoma, a tumor of the developing sympathetic nervous system, is a common childhood neoplasm that is often lethal. Mitochondrial DNA (mtDNA) mutations have been found in most tumors including neuroblastoma. We extracted mtDNA data from a cohort of
Hogarty, Michael D, Calabrese, Francesco Maria, Conte, Massimo, Gasparre, Giuseppe, Lasorsa, Vito Alessandro, Castellano, Aurora, Clima, Rosanna, Pignataro, Piero, CAPASSO, Mario, Hogarty, Michael D., IOLASCON, ACHILLE, Tonini, Gian Paolo   +11 more
core   +1 more source