Results 121 to 130 of about 2,091,584 (306)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

EWS::FLI1 expression in human embryonic mesenchymal stem cells leads to transcriptional reprograming, defective DNA damage repair and Ewing sarcoma

Nature Communications
Ewing sarcoma (ES) is an aggressive bone and soft tissue neoplasm characterized by EWSR::ETS rearrangements whose cellular origin remains unclear. EWS::FLI1 expression in human pediatric mesenchymal stem cells (MSCs) induces a transcriptional response ...
Inmaculada Hernández-Muñoz, Irene Cuervas, Estela Prada, Julian Pulecio, Ramón Gimeno, Evelyn Andrades, Soledad Gómez-González, Pau Berenguer-Molins, Ariadna Acedo-Terrades, Júlia Perera-Bel, Marta Bódalo-Torruella, Lara Nonell, Elena Pérez, Daniela Grases, Caterina Mata, José Yélamos, Yvonne Richaud-Patin, Enrique Vidal, Yasmina Cuartero, François Le Dily, Mariona Suñol, Alejandro Manzanares, Angel Raya, Jaume Mora   +23 more
doaj   +1 more source

Radiosensitivity of surviving cells in tumours pretreated with continuous irradiation: letter

, 1973
Chemicals/CAS: cesium, 7440-46-2; DNA, 9007-49-2; oxygen, 7782-44-7; Cesium Isotopes; DNA, Neoplasm; Oxygen, 7782-44-
Kal, H.B., Barendsen, G.W.
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Genome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) constitutes a rare and aggressive malignancy originating from plasmacytoid dendritic cells (pDCs) with a primarily cutaneous tropism followed by dissemination to the bone marrow and other organs.
Chteinberg, Emil,, Busch, Hauke,, Fischer, Anja,, Witte, Hanno M., Sueltmann, Holger,, Schwarting, Julian,, Kusch, Kathrin, Schwarting, Julian, Fischer, Anja, von Bubnoff, Nikolas, Kuenstner, Axel, Lohneis, Philipp, Chteinberg, Emil, Lohneis, Philipp,, Salehi, Maede, Janke, Florian,, Stölting, Stephanie, Siebert, Reiner,, Bernard, Veronica, Salehi, Maede,, Merz, Hartmut, Kuenstner, Axel,, Chen, Xingqi,, Xing, Pengwei, Sueltmann, Holger, Siebert, Reiner, Gebauer, Niklas,, Künstner, Axel, Janke, Florian, Chen, Xingqi, Busch, Hauke, Xing, Pengwei,, Merz, Hartmut,, von Bubnoff, Nikolas,, Sültmann, Holger, Stoelting, Stephanie, Witte, Hanno M.,, WITTE, HANNO, Stoelting, Stephanie,, Bernard, Veronica,, Gebauer, Niklas, Feller, Alfred C., Kusch, Kathrin,, Feller, Alfred C.,   +43 more
core   +1 more source

DNA structures at chromosomal translocation sites

, 2006
It has been unclear why certain defined DNA regions are consistently sites of chromosomal translocations. Some of these are simply sequences of recognition by endogenous recombination enzymes, but most are not.
Raghavan, Sathees C., Lieber, Michael R.
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Poral neoplasm with combined sebaceous and apocrine differentiation

, 1998
Poromas have been considered the hallmark of benign eccrine neoplasms. The literature describes six cases of poroma differentiating toward apocrine and sebaceous lineage.
A. Coggi, R. Gianotti, E. Alessi
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source