Results 111 to 120 of about 2,091,584 (306)

Genomic analysis of pancreatic juice DNA assesses malignant risk of intraductal papillary mucinous neoplasm of pancreas

Cancer Medicine, 2019
Intraductal papillary mucinous neoplasm (IPMN) of pancreas has a high risk to develop into invasive cancer or co‐occur with malignant lesion. Therefore, it is important to assess its malignant risk by less‐invasive approach.
Raúl N. Mateos, Hidewaki Nakagawa, Seiko Hirono, Shinichi Takano, Mitsuharu Fukasawa, Akio Yanagisawa, Satoru Yasukawa, Kazuhiro Maejima, Aya Oku‐Sasaki, Kaoru Nakano, Munmee Dutta, Hiroko Tanaka, Satoru Miyano, Nobuyuki Enomoto, Hiroki Yamaue, Kenta Nakai, Masashi Fujita   +16 more
doaj   +1 more source

Evaluation Of DNA Extraction From Archieved Formalin-Fixed Paraffin Tissues (FFPT) By β-Globin Gene PCR.

Kufa Journal for Nursing Sciences, 2014
Background: the knowledge of the nucleic acid state before start to molecular detection have a great importance to make a math measurements by which the nucleic acid quantity and quality will be knows.
Asaad Aljanabi, Ahmed Mohammed Ali Nazar, Hashim Raheem Tarish   +2 more
doaj   +1 more source

Increased risk of lymphoid neoplasm in patients with myeloproliferative neoplasm: a study of 1,915 patients.

, 2010
Within a cohort of 1,915 consecutive patients with myeloproliferative neoplasm followed for a median time of 5.2 years (range 0-33.3), we investigated the occurrence of lymphoid neoplasm with the aim of defining this risk and to investigate the role of ...
E. Rumi, S. Zibellini, Elena C, D. Pietra, ELENA, CHIARA, L. Arcaini, PASSAMONTI, FRANCESCO, M. Lazzarino, Pascutto C, RUMI, ELISA, ARCAINI, LUCA, C. Astori, Pietra D, E. Boveri, F. Passamonti, C. Pascutto, Arcaini L, Zibellini S, Rumi E, LAZZARINO, MARIO, Boveri E, Passamonti F, Lazzarino M., Astori C, C. Elena   +24 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Identification of binding mechanisms in single molecule-DNA complexes [PDF]

, 2003
Eckel R, Ros R, Ros A, Wilking SD, Sewald N, Anselmetti D. Identification of binding mechanisms in single molecule-DNA complexes. Biophysical journal. 2003;85(3):1968-1973.Changes in the elastic properties of single deoxyribonucleic acid (DNA) molecules ...
Ros, Robert, Eckel, Rainer, Sven David Wilking, Dario Anselmetti, Robert Ros, Wilking, S.D., Sewald, Norbert ; https://orcid.org/, Ra Ros, Ros, Alexandra, Rainer Eckel, Anselmetti, Dario ; https://orcid.org/, Y Norbert Sewald   +11 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

THE SOFTWARE “MINOR VARIANT FINDER” AS A TOOL FOR ANALYZING THE LEVEL OF ALLELIC LOAD BY SOMATIC MUTATIONS IN HEMATOLOGICAL DISEASES

Siberian Journal of Life Sciences and Agriculture, 2019
The somatic mutation of JAK2 p. 1849 G> T (V617F) leads to cytokine-independent growth of bone marrow cell lines. It is one of the diagnostic criteria for chronic myeloproliferative neoplasm.
Irina Evgenevna Maslyukova, Anastasia Aleksandrovna Karnyushka, Tatiana Nikolaevna Subbotina, Anna Sergeevna Hazieva, Elena Aleksandrovna Dunaeva, Konstantin Olegovich Mironov   +5 more
doaj   +1 more source

Cutaneous CD4+/ CD56 hematodermic neoplasm

, 2010
CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK cell lymphoma, is a rare and aggressive neoplasm with a high incidence of cutaneous involvement, risk of leukemic dissemination and poor prognosis.
Kavala, Mukaddes, Ilkin Zindanci, Kocaturk, Emek, Melek Koc, Mukaddes Kavala, Zindanci, Ilkin, Koc, Melek, Emek Kocaturk, Nesimi Buyukbabani, BÜYÜKBABANİ, Nesimi   +9 more
core   +1 more source

Visualizing helicases unwinding DNA at the single molecule level. [PDF]

, 2010
DNA helicases are motor proteins that catalyze the unwinding of double-stranded DNA into single-stranded DNA using the free energy from ATP hydrolysis. Single molecule approaches enable us to address detailed mechanistic questions about how such enzymes ...
Fili, Natali, Mashanov, Gregory I, Yeeles, Joseph T P, Toseland, Christopher P, Wallace, Mark I, Webb, Martin R, Batters, Christopher, Dillingham, Mark S, Molloy, Justin E   +8 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source