Results 111 to 120 of about 479,747 (308)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Angiogenic Alterations Associated with Circulating Neoplastic DNA in Ovarian Carcinoma

, 2012
OBJECTIVES: Forty percent of women with ovarian carcinoma have circulating free neoplastic DNA identified in plasma. Angiogenesis is critical in neoplastic growth and metastasis.
Goff, Barbara A., Shah, Chirag A., Swisher, Elizabeth M., Welcsh, Piri, Vogel, Tilley Jenkins, Garcia, Rochelle L., DelloRusso, Christiana   +6 more
core   +1 more source

DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

Nature Communications
Abstract Neuroendocrine neoplasms (NEN) are thought to originate from diffuse neuroendocrine networks and therefore most frequently arise in the gastrointestinal tract and lungs. The liver is a frequent site of metastasis of NEN but also the existence of primary hepatic NEN has been proposed.
Benjamin Goeppert, Alphonse Charbel, Reka Toth, Yue Zhang, Danial Tabbakh, Thomas Albrecht, Daniel Schrimpf, Louis de Mestier, Jérôme Cros, Monika Nadja Vogel, De-Hua Chang, Eva-Marie Bohn, Alexander Brobeil, Junfang Ji, Stephan Singer, Petr V. Nazarov, Aurel Perren, Leonidas Apostolidis, Andreas von Deimling, Stephanie Roessler   +19 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Evaluation Of DNA Extraction From Archieved Formalin-Fixed Paraffin Tissues (FFPT) By β-Globin Gene PCR.

Kufa Journal for Nursing Sciences, 2014
Background: the knowledge of the nucleic acid state before start to molecular detection have a great importance to make a math measurements by which the nucleic acid quantity and quality will be knows.
Asaad Aljanabi, Ahmed Mohammed Ali Nazar, Hashim Raheem Tarish   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

THE SOFTWARE “MINOR VARIANT FINDER” AS A TOOL FOR ANALYZING THE LEVEL OF ALLELIC LOAD BY SOMATIC MUTATIONS IN HEMATOLOGICAL DISEASES

Siberian Journal of Life Sciences and Agriculture, 2019
The somatic mutation of JAK2 p. 1849 G> T (V617F) leads to cytokine-independent growth of bone marrow cell lines. It is one of the diagnostic criteria for chronic myeloproliferative neoplasm.
Irina Evgenevna Maslyukova, Anastasia Aleksandrovna Karnyushka, Tatiana Nikolaevna Subbotina, Anna Sergeevna Hazieva, Elena Aleksandrovna Dunaeva, Konstantin Olegovich Mironov   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Searching for gene expression differences in primary fibroblasts between patients with one and two neoplasms in childhood

, 2013
Genetic factors are important for developing primary and subsequent malignancies in children. This study investigated the role of genetic factors involved in DNA-repair.
Victor, A., Weis, E., Marron, M., Haaf, T., Galetzka, D., Messow, C-M., Spix, C.   +6 more
core   +1 more source