Results 131 to 140 of about 2,091,584 (306)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
, 2013 We describe a case of posterior fossa blastomycosis in an immunocompetent patient that mimicked high-grade neoplasm on neuroimaging. Histological analysis confirmed blastomycosis.
Saurabh Guleria +3 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Cancer-related gene profiling in resected pancreatic tumours.
, 2014 VF, Variant frequency; WT, wild type;PDAC, pancreatic ductal adenocarcinoma; IPMN, intraductal papillary mucinous neoplasm.†DNA from formalin-fixed, paraffin-embedded samples.
Mika Miura (205029) +8 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
, 2019 Extensive phenotyping; trio setup,Data categories: Biological samples Material collected: DNA Number of donors: 600 Sex: Unknown Diseases studied: Malignant neoplasm of thyroid ...
Links, Thera +2 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Temporal relationship between the diagnoses of a brain neoplasm and CPP in 15 patients.
, 2018 Squares indicate diagnosis of a brain neoplasm and triangles indicate CPP diagnosis. White squares indicate CPP diagnosed after the brain neoplasm, while gray squares indicate CPP diagnosis prior to neoplasm diagnosis. (TIF)
Courtney L. Gilbert (5459651) +5 more
core +1 more source