Results 161 to 170 of about 2,091,584 (306)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Transformation From Oxyntic Gland Neoplasm Into Advanced Gastric Cancer via <i>TP53</i> Mutation: A First Case Report. [PDF]

J Med Cases
Komatsu A, Rokutan H, Arai N, Nagasaka T, Kamino S, Fukagawa K, Ono S, Kanazawa N, Arai T.   +8 more
europepmc   +1 more source

Intraductal oncocytic papillary neoplasm of the pancreas

Intraductal oncocytic papillary neoplasm is a rare tumor of pancreatic duct epithelia with a good prognosis. The tumor has unique morphologic and genetic properties that distinguish it from intraductal papillary mucinous neoplasm.
I.A. Martinkevich, K.A. Pavlov, E.A. Dubova   +2 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Case Report: High-grade supratentorial CNS neoplasm with <i>EP300::BCOR</i> fusion in an adult: expanding the morphologic and molecular spectrum of <i>BCOR</i>-fused tumors. [PDF]

Front Oncol
Abdulkader-Sande S, Garrido A, Durán-Cameselle A, Fiaño-Valverde C, Ruiz-de Almiron L, Perez B, Fernandez-Perez I.   +6 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Using cell free DNA (cfDNA) and RNA (cfRNA) in the diagnosis and monitoring of primary and metastatic CNS tumors. [PDF]

J Liq Biopsy
Albitar M, Charifa A, Agersborg S, Butt O, Albitar A, Gatson NTN, Goy A, Kesari S.   +7 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastoma With an Unusual EWSR1::RAD51B Gene Fusion: A Case Report and Review of the Literature. [PDF]

Cureus
Al-Mustafa S, Al-Kawaaz M, Paul L, Franchitti A, Aldape KM, Hattab EM.   +5 more
europepmc   +1 more source