Results 251 to 260 of about 479,747 (308)

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

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DNA methylation in thoracic neoplasms

Cancer Letters, 2011
Thoracic neoplasms, which include lung cancers, esophageal carcinoma, and thymic epithelial tumors, are the leading causes of tumor-related death and a major health concern worldwide. The development of neoplasms is a multistep process involving both genetic and epigenetic alterations.
Chen, Chen, Ni, Yin, Bangliang, Yin, Qianjin, Lu   +3 more
openaire   +2 more sources

DNA Flow Cytometry of Thyroid Neoplasms

Archives of Otolaryngology - Head and Neck Surgery, 1985
Mechanically dispersed cell suspensions from 23 thyroid lesions were studied by acridine orange flow cytometry. Eight of 14 carcinomas (three papillary, two medullary, two Hürthle cell, and one follicular) manifested abnormal DNA indices ranging from 0.6 to 2.0. Six carcinomas (four papillary and two medullary) were diploid.
B B, Kraemer, J R, Srigley, J G, Batsakis, E G, Silva, H, Goepfert   +4 more
openaire   +2 more sources

Apoptosis Identified by DNA Fragmentation in Epidermal Neoplasms

The Journal of Dermatology, 1995
AbstractIn the previous study, we demonstrated apoptotic cells in basal cell carcinomas by means of terminal deoxynucleotidyl transferase‐mediated dUTP‐biotin nick end labeling (TUNEL). Positive staining cells were present at the peripheries and centers of the nests.
O, Mori, H, Hachisuka, C, Kiyokawa, Y, Sasai   +3 more
openaire   +2 more sources

DNA content is associated with malignancy of intracranial neoplasms

Clinical Neurology and Neurosurgery, 2013
Flow cytometry has been applied to analyze the DNA-content distribution of tumors, in order to relate this to clinical and biological parameters of tumor behavior. Herewith, we investigated the value of cell cycle analysis in the characterization of intracranial lesions and its possible prognostic role.DNA analysis was performed in tumor samples that ...
George A, Alexiou, Evrysthenis, Vartholomatos, Anna, Goussia, Leukothea, Dova, Achilleas, Karamoutsios, George, Fotakopoulos, Athanasios P, Kyritsis, Spyridon, Voulgaris   +7 more
openaire   +2 more sources

Alterations in chromosomes and DNA content in gynecologic neoplasms

American Journal of Obstetrics and Gynecology, 1969
As a result of chromosome examinations of a variety of normal and neoplastic tissues and the study of their nuclear DNA content, it is possible to make broad generalizations regarding alterations in nuclear genetic material in neoplasia. The work to date in gynecologic neoplasms is reviewed and summarized and the etiologic and diagnostic ramifications ...
R, Richart, A S, Ludwig
openaire   +2 more sources

Expression of DNA repair gene Ku80 in lymphoid neoplasm

European Journal of Haematology, 2005
Abstract:  Objectives: Ku, a heterodimer of KU70 and Ku80 that binds to double‐strand DNA breaks (DSBs) and activates the catalytic subunit (DNA‐PKcs) when DNA is bound, is essential in DSB repair and V(D)J recombination. Ku80 is a putative tumor suppressor gene that might play an important role in drug resistance. Our aim was to determine the role of
Tsai-Yun, Chen, Jiann-Shiuh, Chen, Wu-Chou, Su, Ming-Shiuan, Wu, Chao-Jung, Tsao   +4 more
openaire   +2 more sources

Quantitative DNA analysis of small renal cortical neoplasms

Human Pathology, 1991
DNA aneuploidy is common in large renal cortical neoplasms (RCNs), but the incidence in small RCNs is not known. This study was undertaken to investigate whether the traditional 3.0-cm size distinction between small (benign) and large (malignant) tumors might have an objective correlate in the form of abnormal DNA content. Quantitative DNA analysis was
B F, Banner, M S, Ernstoff, R R, Bahnson, L, Titus-Ernstoff, S R, Taylor   +4 more
openaire   +2 more sources