Results 261 to 270 of about 502,740 (312)

DNA Flow Cytometry of Thyroid Neoplasms

Archives of Otolaryngology - Head and Neck Surgery, 1985
Mechanically dispersed cell suspensions from 23 thyroid lesions were studied by acridine orange flow cytometry. Eight of 14 carcinomas (three papillary, two medullary, two Hürthle cell, and one follicular) manifested abnormal DNA indices ranging from 0.6 to 2.0. Six carcinomas (four papillary and two medullary) were diploid.
B B, Kraemer, J R, Srigley, J G, Batsakis, E G, Silva, H, Goepfert   +4 more
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Apoptosis Identified by DNA Fragmentation in Epidermal Neoplasms

The Journal of Dermatology, 1995
AbstractIn the previous study, we demonstrated apoptotic cells in basal cell carcinomas by means of terminal deoxynucleotidyl transferase‐mediated dUTP‐biotin nick end labeling (TUNEL). Positive staining cells were present at the peripheries and centers of the nests.
O, Mori, H, Hachisuka, C, Kiyokawa, Y, Sasai   +3 more
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Quantitative DNA analysis of small renal cortical neoplasms

Human Pathology, 1991
DNA aneuploidy is common in large renal cortical neoplasms (RCNs), but the incidence in small RCNs is not known. This study was undertaken to investigate whether the traditional 3.0-cm size distinction between small (benign) and large (malignant) tumors might have an objective correlate in the form of abnormal DNA content. Quantitative DNA analysis was
B F, Banner, M S, Ernstoff, R R, Bahnson, L, Titus-Ernstoff, S R, Taylor   +4 more
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DNA content is associated with malignancy of intracranial neoplasms

Clinical Neurology and Neurosurgery, 2013
Flow cytometry has been applied to analyze the DNA-content distribution of tumors, in order to relate this to clinical and biological parameters of tumor behavior. Herewith, we investigated the value of cell cycle analysis in the characterization of intracranial lesions and its possible prognostic role.DNA analysis was performed in tumor samples that ...
George A, Alexiou, Evrysthenis, Vartholomatos, Anna, Goussia, Leukothea, Dova, Achilleas, Karamoutsios, George, Fotakopoulos, Athanasios P, Kyritsis, Spyridon, Voulgaris   +7 more
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Alterations in chromosomes and DNA content in gynecologic neoplasms

American Journal of Obstetrics and Gynecology, 1969
As a result of chromosome examinations of a variety of normal and neoplastic tissues and the study of their nuclear DNA content, it is possible to make broad generalizations regarding alterations in nuclear genetic material in neoplasia. The work to date in gynecologic neoplasms is reviewed and summarized and the etiologic and diagnostic ramifications ...
R, Richart, A S, Ludwig
openaire   +2 more sources

Expression of DNA repair gene Ku80 in lymphoid neoplasm

European Journal of Haematology, 2005
Abstract:  Objectives: Ku, a heterodimer of KU70 and Ku80 that binds to double‐strand DNA breaks (DSBs) and activates the catalytic subunit (DNA‐PKcs) when DNA is bound, is essential in DSB repair and V(D)J recombination. Ku80 is a putative tumor suppressor gene that might play an important role in drug resistance. Our aim was to determine the role of
Tsai-Yun, Chen, Jiann-Shiuh, Chen, Wu-Chou, Su, Ming-Shiuan, Wu, Chao-Jung, Tsao   +4 more
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Occurrence of Human Papillomavirus DNA in Primary Lung Neoplasms

Cancer, 1992
The occurrence of human papillomavirus (HPV) DNA in primary lung carcinomas and in squamous metaplasia of the bronchus was studied using in situ hybridization techniques and commercially available biotinylated DNA probes to HPV subtypes 6/11, 16/18, and 31/33/35.
S A, Yousem, N P, Ohori, E, Sonmez-Alpan
openaire   +2 more sources

Flow Cytometric DNA and Nuclear Antigen Content in Astrocytic Neoplasms

American Journal of Clinical Pathology, 1988
Simultaneous flow cytometric DNA content and proliferation-associated nuclear antigen (p105) quantitation was performed on 23 astrocytic tumors and the results correlated with histologic subtype. Three of nine anaplastic astrocytomas and one of ten glioblastomas had an identifiable aneuploid peak, while all four well differentiated astrocytomas were ...
P L, Fitzgibbons, R R, Turner, A J, Appley, P C, Bishop, P W, Nichols, A L, Epstein, M L, Apuzzo, P T, Chandrasoma   +7 more
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[DNA methylation and neoplasms].

Casopis lekaru ceskych, 2000
DNA methylation and acetylation of histone proteins represent two global mechanisms controlling the gene expression. DNA methylation profiles alter during the development of the organism and during progression of neoplasia. Three types of alterations of the DNA methylation profiles were observed in the tumor cells: hypomethylation, hypermethylation and
J, Mares, Z, Sedlácek, P, Goetz
openaire   +1 more source

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

Science, 1985
The methylation state of DNA from human colon tissue displaying neoplastic growth was determined by means of restriction endonuclease analysis. When compared to DNA from adjacent normal tissue, DNA from both benign colon polyps and malignant carcinomas was substantially hypomethylated.
S E, Goelz, B, Vogelstein, S R, Hamilton, A P, Feinberg   +3 more
openaire   +2 more sources