Results 1 to 10 of about 142,373 (137)

Decitabine-mediated DNA methylation dynamics at pericentromeric satellite 2 repeats [PDF]

BMC Cancer
The hypomethylating agents (HMAs) 5-azacytidine (vidaza-AZA) and 5-aza-2′-deoxycytidine (decitabine-DAC) are part of the standard of care for the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). However, the molecular events
Enrica Sordini, Eugenia Ciurlia, Alessia Zanella, Benedetta Fogliardi, Dorela Lame, Antonella Poloni, Stefano Amatori, Mirco Fanelli   +7 more
doaj   +2 more sources

Antibiotics induce overexpression of alpha satellite DNA accompanied with epigenetic changes at alpha satellite arrays as well as genome-wide [PDF]

Epigenetics & Chromatin
The transcription of satellite DNA is highly sensitive to environmental factors and represents a source of genomic instability. Therefore, tight regulation of (peri)centromeric transcription is essential for genome maintenance.
Sven Ljubić, Maja Matulić, Damir Đermić, Maria Chiara Feliciello, Alfredo Procino, Đurđica Ugarković, Isidoro Feliciello   +6 more
doaj   +2 more sources

Unveiling unique expression patterns of D20S16 satellite DNA in human embryonic development [PDF]

Scientific Reports
Satellite DNA is essential for chromosome stability and gene regulation, yet its specific roles in early human embryogenesis remain poorly defined. Here, we integrated the complete human genome reference (T2T-CHM13) with RNA-seq data to investigate the ...
Yajie Hu, Kenji Mizuguchi, Kosuke Hashimoto   +2 more
doaj   +2 more sources

Differential enrichment of H3K9me3 at annotated satellite DNA repeats in human cell lines and during fetal development in mouse

Epigenetics & Chromatin, 2021
Background Trimethylation of histone H3 on lysine 9 (H3K9me3) at satellite DNA sequences has been primarily studied at (peri)centromeric regions, where its level shows differences associated with various processes such as development and malignant ...
Tanja Vojvoda Zeljko, Đurđica Ugarković, Željka Pezer   +2 more
doaj   +1 more source

Uhrf1 governs the proliferation and differentiation of muscle satellite cells

iScience, 2022
Summary: DNA methylation is an essential form of epigenetic regulation responsible for cellular identity. In muscle stem cells, termed satellite cells, DNA methylation patterns are tightly regulated during differentiation.
Hiroshi Sakai, Yuichiro Sawada, Naohito Tokunaga, Kaori Tanaka, So Nakagawa, Iori Sakakibara, Yusuke Ono, So-ichiro Fukada, Yasuyuki Ohkawa, Tadahiko Kikugawa, Takashi Saika, Yuuki Imai   +11 more
doaj   +1 more source

Locational diversity of alpha satellite DNA and intergeneric hybridization aspects in the Nomascus and Hylobates genera of small apes. [PDF]

PLoS ONE, 2014
Recently, we discovered that alpha satellite DNA has unique and genus-specific localizations on the chromosomes of small apes. This study describes the details of alpha satellite localization in the genera Nomascus and Hylobates and explores their ...
Sudarath Baicharoen, Takako Miyabe-Nishiwaki, Visit Arsaithamkul, Yuriko Hirai, Kwanruen Duangsa-ard, Boripat Siriaroonrat, Hiroshi Domae, Kornsorn Srikulnath, Akihiko Koga, Hirohisa Hirai   +9 more
doaj   +1 more source

Satellitome of the Red Palm Weevil, Rhynchophorus ferrugineus (Coleoptera: Curculionidae), the Most Diverse Among Insects

Frontiers in Ecology and Evolution, 2022
The red palm weevil, Rhynchophorus ferrugineus, is the most harmful species among those pests affecting palm trees. Its impact causes important economic losses around the World. Nevertheless, the genetic information of Rh.
Eugenia E. Montiel, Pablo Mora, José M. Rico-Porras, Teresa Palomeque, Pedro Lorite   +4 more
doaj   +1 more source

Satellitome Analysis and Transposable Elements Comparison in Geographically Distant Populations of Spodoptera frugiperda

Life, 2022
Spodoptera frugiperda (fall armyworm) is a member of the superfamily Noctuoidea that accounts for more than a third of all Lepidoptera and includes a considerable number of agricultural and forest pest species.
Inzamam Ul Haq, Majid Muhammad, Huang Yuan, Shahbaz Ali, Asim Abbasi, Muhammad Asad, Hafiza Javaria Ashraf, Aroosa Khurshid, Kexin Zhang, Qiangyan Zhang, Changzhong Liu   +10 more
doaj   +1 more source

Uncoupling of satellite DNA and centromeric function in the genus Equus. [PDF]

PLoS Genetics, 2010
In a previous study, we showed that centromere repositioning, that is the shift along the chromosome of the centromeric function without DNA sequence rearrangement, has occurred frequently during the evolution of the genus Equus.
Francesca M Piras, Solomon G Nergadze, Elisa Magnani, Livia Bertoni, Carmen Attolini, Lela Khoriauli, Elena Raimondi, Elena Giulotto   +7 more
doaj   +1 more source

Identification and characterization of a new family of long satellite DNA, specific of true toads (Anura, Amphibia, Bufonidae)

Scientific Reports, 2022
Amphibians have some of the most variable genome sizes among vertebrates. Genome size variation has been attributed to repetitive and noncoding DNA, including satellite repeats, transposable elements, introns, and nuclear insertions of viral and ...
Katerina Guzmán, Álvaro S. Roco, Matthias Stöck, Adrián Ruiz-García, Enrique García-Muñoz, Mónica Bullejos   +5 more
doaj   +1 more source